456-12-2
N-Cinnamoyl-β-hydroxy-4-methoxyphenyl-aethylamin
CAS: 456-12-2
Molecular Formula: C18H19NO3
456-12-2 - Names and Identifiers
456-12-2 - Physico-chemical Properties
| Molecular Formula | C18H19NO3 |
| Molar Mass | 297.35 |
| Melting Point | 178-179℃ |
| Appearance | powder to crystal |
| Color | White to Light yellow |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Aegeline also prevents growth block in cells expressing the more toxic A53T α-synuclein mutant. Restoration of cell growth occurred through inhibition of increased ROS levels, mitochondrial membrane potential loss and nuclear DNA fragmentation, characteristics of apoptosis manifested in α-synuclein or Bax-expressing cells. Aegeline shows weak inhibitory effects on the histamine release from RPMCs, even though still succeed to inhibit when the histamine release induced by thapsigargin. |
456-12-2 - Reference Information
| Use | Indullum is a compound that can be extracted from the leaves of Aegle marmelos trees growing in India. The study found that the essential oil of this tree is effective against 21 species of bacteria. Dizulinine also has an anti-obesity effect. Aromatic derivatives can be used as intermediates in pharmaceutical synthesis. |
| Biological activity | Aegeline is a major alkaloid that simulates yeast SNARE protein Sec22p to inhibit yeast α-synuclein and Bax toxicity. Yeast cell growth inhibited by αsyn or Bax was Aegeline restored. |
Last Update：2024-04-09 20:52:54
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Product Name: Aegeline Visit Supplier Webpage Request for quotationCAS: 456-12-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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