456-24-6
2-Fluoro-5-nitropyridine
CAS: 456-24-6
Molecular Formula: C5H3FN2O2
456-24-6 - Names and Identifiers
| Name | 2-Fluoro-5-nitropyridine |
| Synonyms | uoro-5-nitropyridine 2-Fluor-5-nitropyridin 2-FLUORO-5-NITROPYRIDINE 6-FLUORO-3-NITROPYRIDINE 2-Fluoro-5-nitropyridine Pyridine, 2-fluoro-5-nitro- |
| CAS | 456-24-6 |
| EINECS | 207-260-6 |
| InChI | InChI=1/C5H3FN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H |
456-24-6 - Physico-chemical Properties
| Molecular Formula | C5H3FN2O2 |
| Molar Mass | 142.09 |
| Density | 4,64g/cm |
| Melting Point | 142-144 C |
| Boling Point | 86-87℃/7mm lit. |
| Flash Point | 97.5°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 0.0686mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| pKa | -4.47±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.5250 |
| MDL | MFCD03095059 |
456-24-6 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | UN 1549 |
456-24-6 - Introduction
2-Fluoro-5-nitropyridine (2-Fluoro-5-nitropyridine) is an organic compound with the chemical formula C5H3FN2O2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2-Fluoro-5-nitropyridine is a white to pale yellow solid.
-Solubility: It can be dissolved in many organic solvents, such as ethanol, dimethylformamide and dichloromethane.
-Melting point: Its melting point is about 78-81 degrees Celsius.
Use:
- 2-Fluoro-5-nitropyridine is an effective organic synthesis intermediate, which has important uses in the manufacture of drugs and pesticides.
-It can be used to synthesize a variety of biologically active compounds, such as pharmaceuticals, dyes and coatings.
Preparation Method:
- 2-Fluoro-5-nitropyridine is generally prepared by the fluorination and nitration of pyridine.
-The specific preparation method may be reacting pyridine with hydrogen fluoride or ammonium fluoride to obtain 2-fluoropyridine. The 2-fluoropyridine is then reacted with nitric acid to give 2-Fluoro-5-nitropyridine.
Safety Information:
- 2-Fluoro-5-nitropyridine is an organic compound with a certain degree of danger. In the process of operation, it is necessary to abide by the relevant safety operation regulations.
-It may be irritating to the skin and eyes, so protective measures should be taken when exposed, such as wearing protective gloves and goggles.
-If accidentally ingested or inhaled, seek medical attention and give appropriate first aid measures.
-During storage, 2-Fluoro-5-nitropyridine should be stored in a dry, cool place, away from fire and oxidizing agents.
Nature:
-Appearance: 2-Fluoro-5-nitropyridine is a white to pale yellow solid.
-Solubility: It can be dissolved in many organic solvents, such as ethanol, dimethylformamide and dichloromethane.
-Melting point: Its melting point is about 78-81 degrees Celsius.
Use:
- 2-Fluoro-5-nitropyridine is an effective organic synthesis intermediate, which has important uses in the manufacture of drugs and pesticides.
-It can be used to synthesize a variety of biologically active compounds, such as pharmaceuticals, dyes and coatings.
Preparation Method:
- 2-Fluoro-5-nitropyridine is generally prepared by the fluorination and nitration of pyridine.
-The specific preparation method may be reacting pyridine with hydrogen fluoride or ammonium fluoride to obtain 2-fluoropyridine. The 2-fluoropyridine is then reacted with nitric acid to give 2-Fluoro-5-nitropyridine.
Safety Information:
- 2-Fluoro-5-nitropyridine is an organic compound with a certain degree of danger. In the process of operation, it is necessary to abide by the relevant safety operation regulations.
-It may be irritating to the skin and eyes, so protective measures should be taken when exposed, such as wearing protective gloves and goggles.
-If accidentally ingested or inhaled, seek medical attention and give appropriate first aid measures.
-During storage, 2-Fluoro-5-nitropyridine should be stored in a dry, cool place, away from fire and oxidizing agents.
Last Update：2024-04-09 20:49:11
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