45660-95-5
2-Chloro-3-(chloromethyl)pyrazine
CAS: 45660-95-5
Molecular Formula: C5H4Cl2N2
45660-95-5 - Names and Identifiers
| Name | 2-Chloro-3-(chloromethyl)pyrazine |
| Synonyms | 2-Chloromethyl-3-chloropyrazine 2-Chloro-3-(chloromethyl)pyrazine Pyrazine, 2-chloro-3-(chloromethyl)- |
| CAS | 45660-95-5 |
45660-95-5 - Physico-chemical Properties
| Molecular Formula | C5H4Cl2N2 |
| Molar Mass | 163 |
| Density | 1.410 |
| Boling Point | 230℃ |
| Flash Point | 115℃ |
| pKa | -2.39±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD15144508 |
45660-95-5 - Introduction
2-Chloro-3-(chloromethyl)pyrazine, also known as 2-chloro-3-(chloromethyl) pyrimidine, is an organic compound. Its chemical formula is C5H5Cl2N2 and its molecular weight is 158.01. It is a colorless to yellowish liquid with a pungent odor.
This compound is commonly used in organic synthesis and pharmaceutical research. It can be used as an intermediate in the synthesis of other organic compounds. For example, it can be used to prepare organic heterocyclic compounds containing a chloromethyl group.
The method for preparing 2-chloro-3-(chloromethyl) pyrimidine includes the following steps:
1. first prepare 2-chloro -3-tert-butyl pyrimidine. 2-Butanol and 2-chloro-3-bromoacetone are reacted in the presence of a base catalyst to produce 2-chloro-3-tert-butylpyrimidine.
2. The chlorination reaction is then carried out to react 2-chloro-3-tert-butyl pyrimidine with methyl chloride to generate 2-chloro-3-(chloromethyl) pyrimidine.
For safety information, please note the following:
1. The compound is irritating, and contact with skin and eyes may cause burning and irritation. Use gloves and goggles to avoid direct contact.
2. During use and operation, ensure that it is carried out in a well-ventilated area and avoid inhaling its vapor.
3. Due to insufficient toxicity data, try to avoid swallowing and entering the respiratory tract of the substance. If ingested or inhaled, seek medical attention immediately.
4. it is strictly forbidden to mix the compound with strong oxidant, strong acid, strong alkali, etc.
This compound is commonly used in organic synthesis and pharmaceutical research. It can be used as an intermediate in the synthesis of other organic compounds. For example, it can be used to prepare organic heterocyclic compounds containing a chloromethyl group.
The method for preparing 2-chloro-3-(chloromethyl) pyrimidine includes the following steps:
1. first prepare 2-chloro -3-tert-butyl pyrimidine. 2-Butanol and 2-chloro-3-bromoacetone are reacted in the presence of a base catalyst to produce 2-chloro-3-tert-butylpyrimidine.
2. The chlorination reaction is then carried out to react 2-chloro-3-tert-butyl pyrimidine with methyl chloride to generate 2-chloro-3-(chloromethyl) pyrimidine.
For safety information, please note the following:
1. The compound is irritating, and contact with skin and eyes may cause burning and irritation. Use gloves and goggles to avoid direct contact.
2. During use and operation, ensure that it is carried out in a well-ventilated area and avoid inhaling its vapor.
3. Due to insufficient toxicity data, try to avoid swallowing and entering the respiratory tract of the substance. If ingested or inhaled, seek medical attention immediately.
4. it is strictly forbidden to mix the compound with strong oxidant, strong acid, strong alkali, etc.
Last Update：2024-04-09 21:04:16
