458-10-6
N-(3-fluoro-4-methylphenyl)acetamide
CAS: 458-10-6
Molecular Formula: C9H10FNO
458-10-6 - Names and Identifiers
| Name | N-(3-fluoro-4-methylphenyl)acetamide |
| Synonyms | NSC 57471 3'-Fluoro-4'-methylacetanilide N-(3-fluoro-4-methylphenyl)acetamide N-(3-fluoro-4-methyl-phenyl)acetamide Acetamide, N-(3-fluoro-4-methylphenyl)- |
| CAS | 458-10-6 |
| InChI | InChI=1/C9H10FNO/c1-6-3-4-8(5-9(6)10)11-7(2)12/h3-5H,1-2H3,(H,11,12) |
458-10-6 - Physico-chemical Properties
| Molecular Formula | C9H10FNO |
| Molar Mass | 167.18 |
| Density | 1.169g/cm3 |
| Boling Point | 296.7°C at 760 mmHg |
| Flash Point | 133.2°C |
| Vapor Presure | 0.00141mmHg at 25°C |
| Refractive Index | 1.546 |
458-10-6 - Introduction
N-(3-fluoro-4-methylphenyl)acetamide(N-(3-fluoro-4-methylphenyl)acetamide) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: This compound is a white crystalline powder.
-Storage conditions: It should be stored in a dry, cool place, away from fire and combustibles.
-Solubility: It has good solubility in common organic solvents.
Use:
- N-(3-fluoro-4-methylphenyl)acetamide can be used as a raw material for pesticide intermediates and pharmaceutical intermediates.
-It can also be used in organic synthesis reactions, for example, as an introducing agent for amide groups.
Preparation Method:
A common preparation method is to prepare N-(3-fluoro-4-methylphenyl)acetamide through an amidation reaction. The specific preparation steps are as follows:
1. Dissolve 3-fluoro-4-methylaniline and acetic anhydride in a suitable solvent.
2. Add a base catalyst (e. g., sodium carbonate).
3. The reaction temperature is generally room temperature, and it is necessary to keep the reaction mixture stirred.
4. After completion of the reaction, the product was washed with water.
5. Finally, the target compound was obtained by a crystallization operation.
Safety Information:
-When using or storing N-(3-fluoro-4-methylphenyl)acetamide, take care to prevent contact with skin, eyes, and respiratory tract.
-Need to operate in a well-ventilated place, it is recommended to wear protective gloves and protective glasses.
-If inhaled or taken by mistake, seek medical attention immediately and provide the product's safety data sheet.
Please note that when handling chemical substances, always follow the actual situation and
Nature:
-Appearance: This compound is a white crystalline powder.
-Storage conditions: It should be stored in a dry, cool place, away from fire and combustibles.
-Solubility: It has good solubility in common organic solvents.
Use:
- N-(3-fluoro-4-methylphenyl)acetamide can be used as a raw material for pesticide intermediates and pharmaceutical intermediates.
-It can also be used in organic synthesis reactions, for example, as an introducing agent for amide groups.
Preparation Method:
A common preparation method is to prepare N-(3-fluoro-4-methylphenyl)acetamide through an amidation reaction. The specific preparation steps are as follows:
1. Dissolve 3-fluoro-4-methylaniline and acetic anhydride in a suitable solvent.
2. Add a base catalyst (e. g., sodium carbonate).
3. The reaction temperature is generally room temperature, and it is necessary to keep the reaction mixture stirred.
4. After completion of the reaction, the product was washed with water.
5. Finally, the target compound was obtained by a crystallization operation.
Safety Information:
-When using or storing N-(3-fluoro-4-methylphenyl)acetamide, take care to prevent contact with skin, eyes, and respiratory tract.
-Need to operate in a well-ventilated place, it is recommended to wear protective gloves and protective glasses.
-If inhaled or taken by mistake, seek medical attention immediately and provide the product's safety data sheet.
Please note that when handling chemical substances, always follow the actual situation and
Last Update：2024-04-09 21:00:56
