458-52-6

458-52-6 - Names and Identifiers

Name	4-Methoxy-2-fluoroaniline
Synonyms	4-Fluoro4-Methoxyaniline 4-Methoxy-2-fluoroaniline 2-FLUORO-4-METHOXYANILINE 4-fluoro-3-methoxyaniline 2-Fluoro-4-methoxyaniline 2-fluoro-4-MethoxybenzenaMine 2-Fluoro-4-methoxyaniline, JRD (2-fluoro-4-methoxyphenyl)amine 1HCl 4-Methoxy-2-fluoroaniline hydrochloride
CAS	458-52-6
InChI	InChI=1/C7H8FNO/c1-10-5-2-3-7(9)6(8)4-5/h2-4H,9H2,1H3

458-52-6 - Physico-chemical Properties

Molecular Formula	C7H8FNO
Molar Mass	141.14
Density	1.176±0.06 g/cm3(Predicted)
Melting Point	175°C
Boling Point	203.0±20.0 °C(Predicted)
Flash Point	76.6°C
Vapor Presure	0.284mmHg at 25°C
Appearance	Yellow solid
pKa	3.81±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.531
MDL	MFCD00047827

458-52-6 - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	6.1

458-52-6 - Introduction

4-Methoxy-2-fluoroaniline is an organic compound with the chemical formula C7H8FNO. The following is a detailed description of its nature, use, formulation and safety information:

Nature:
4-Methoxy-2-fluoroaniline is a solid substance with a white crystalline appearance. It has a melting point of 63-65 degrees Celsius and a boiling point of 235-237 degrees Celsius. It is soluble in organic solvents such as ethanol and dimethyl sulfoxide at normal temperature.

Use:
4-Methoxy-2-fluoroaniline is commonly used as an intermediate in organic synthesis. It can be used to synthesize a variety of organic compounds, such as aromatic amines and fluorinated aromatic hydrocarbons. In the field of medicine, it can also be used for the preparation of drugs for the treatment of cancer, such as certain anti-tumor agents.

Preparation Method:
The preparation of 4-Methoxy-2-fluoroaniline is usually obtained by fluorination of methylbenzoamide (4-methoxybenzamide). A specific preparation method may be to react methylbenzoin amide with sodium hypochlorite and hydrofluoric acid, followed by reduction to form the corresponding amine.

Safety Information:
For any chemical substance, safety needs attention. When handling 4-Methoxy-2-fluoroaniline, appropriate safety measures are required, including wearing protective glasses, gloves and laboratory coats to prevent contact with skin and eyes. Also maintain a well-ventilated working environment and prohibit inhalation, swallowing or contact with the substance. If an accident occurs, immediately flush the affected area with plenty of water and seek medical examination.

Last Update：2024-04-09 02:00:46