46053-72-9
5-nitro-isoindoline
CAS: 46053-72-9
Molecular Formula: C8H8N2O2
46053-72-9 - Names and Identifiers
| Name | 5-nitro-isoindoline |
| Synonyms | 5-NITROISOINDOL 5-NITROISOINDOLINE 5-nitro-isoindoline 2,3-dihydro-5-nitro-1H-Isoindole 5-Nitro-2,3-dihydro-1H-isoindole 1H-Isoindole, 2,3-dihydro-5-nitro- |
| CAS | 46053-72-9 |
| InChI | InChI=1S/C8H8N2O2/c11-10(12)8-2-1-6-4-9-5-7(6)3-8/h1-3,9H,4-5H2 |
46053-72-9 - Physico-chemical Properties
| Molecular Formula | C8H8N2O2 |
| Molar Mass | 164.16 |
| Density | 1.298 |
| Boling Point | 293℃ |
| Flash Point | 131℃ |
| pKa | 7.56±0.20(Predicted) |
| Storage Condition | 2-8°C |
46053-72-9 - Introduction
5-nyro-isoindoline (5-nyro-isoindoline) is an organic compound with the chemical formula C8H6N2O2.
Nature:
5-nitro-isoindoline is a colorless to pale yellow crystal with a special odor. It is a kind of organic nitrate compounds, with a certain degree of oxidation and explosive. It is stable at room temperature, but it is explosive when heated, rubbed or impacted. It is dissolved in organic solvents, such as ethanol, ether, etc.
Use:
5-nitro-isoindoline is mainly used as a raw material and intermediate in organic synthesis reactions. It can be reduced to 5-aminoisoindoline in certain reactions to give other organic compounds.
Preparation Method:
5-nitro-isoindoline can be obtained by the reaction of p-nitroaniline and pyridine-2, 4-dimethylone. The specific synthesis path is as follows:
1. Under acidic conditions, nitroaniline and pyridine -2,4-dimethyl ketone are reacted to obtain 5-nitropyridine -2,4-dimethyl ketone.
2. Hydrogenation reaction is carried out to obtain the hydride of 5-nitropyridine-2, 4-dimethylketone.
3. Under acidic conditions, the hydride is reacted with chloroethanol to obtain 5-nitro-isoindoline.
Safety Information:
5-nitro-isoindoline is a combustible and organic explosive that is explosive. Attention should be paid to fire prevention and explosion prevention during operation and storage. Contact or inhalation of 5-nitro-isoindoline may cause health hazards to humans, including skin irritation, eye irritation and respiratory tract irritation. Appropriate personal protective equipment such as gloves, goggles and gas masks should be worn during operation. Any personnel handling the compound should be professionally trained.
Nature:
5-nitro-isoindoline is a colorless to pale yellow crystal with a special odor. It is a kind of organic nitrate compounds, with a certain degree of oxidation and explosive. It is stable at room temperature, but it is explosive when heated, rubbed or impacted. It is dissolved in organic solvents, such as ethanol, ether, etc.
Use:
5-nitro-isoindoline is mainly used as a raw material and intermediate in organic synthesis reactions. It can be reduced to 5-aminoisoindoline in certain reactions to give other organic compounds.
Preparation Method:
5-nitro-isoindoline can be obtained by the reaction of p-nitroaniline and pyridine-2, 4-dimethylone. The specific synthesis path is as follows:
1. Under acidic conditions, nitroaniline and pyridine -2,4-dimethyl ketone are reacted to obtain 5-nitropyridine -2,4-dimethyl ketone.
2. Hydrogenation reaction is carried out to obtain the hydride of 5-nitropyridine-2, 4-dimethylketone.
3. Under acidic conditions, the hydride is reacted with chloroethanol to obtain 5-nitro-isoindoline.
Safety Information:
5-nitro-isoindoline is a combustible and organic explosive that is explosive. Attention should be paid to fire prevention and explosion prevention during operation and storage. Contact or inhalation of 5-nitro-isoindoline may cause health hazards to humans, including skin irritation, eye irritation and respiratory tract irritation. Appropriate personal protective equipment such as gloves, goggles and gas masks should be worn during operation. Any personnel handling the compound should be professionally trained.
Last Update：2024-04-10 22:29:15
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CAS: 46053-72-9
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CAS: 46053-72-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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