474-58-8
Daucosterol
CAS: 474-58-8
Molecular Formula: C35H60O6
474-58-8 - Names and Identifiers
| Name | Daucosterol |
| Synonyms | Daucosterol coriandrinol Carrot glycoside beta-sitosterolglucoside beta-sitosterylglucoside beta-sitosterolmonoglucoside 3-beta-(beta-d-glucopyranosyloxy)-stigmast-5-en 3-beta-(beta-d-glucopyranosyloxy)stigmast-5-ene (3-beta)-stigmast-5-en-3-yl-beta-d-glucopyranoside |
| CAS | 474-58-8 |
| EINECS | 1592732-453-0 |
| InChIKey | YITHQYDRZAVJHB-WWJUBMRMSA-N |
474-58-8 - Physico-chemical Properties
| Molecular Formula | C35H60O6 |
| Molar Mass | 576.86 |
| Density | 1.13±0.1 g/cm3(Predicted) |
| Melting Point | 283～286℃ |
| Boling Point | 673.6±55.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.4 in Py)-41.5 |
| Flash Point | 361℃ |
| Solubility | DMSO (Slightly,Heated), Pyridine (Slightly, Sonicated) |
| Appearance | White powder |
| Color | Off-White to Pale Beige |
| pKa | 12.91±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD01683621 |
474-58-8 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
| Toxicity | LD50 intraperitoneal in mouse: 62mg/kg |
474-58-8 - Reference
| Reference Show more | 1. Han zinqi, Xiao Yanfang, Hao Fuyi, etc. Effect of Raphanin on diabetes in db/db mice [J]. Journal of Health Research, 2020, 25 (2):325-326. 2. Lin Hui, Zhao Ting, Ren Qingjia, et al. Study on the method of thin layer identification of the Tibetan Medicine of the Horse [J]. World Science and Technology-modernization of traditional Chinese medicine, 2014(12). 3. Wang Xiangpeng, Wu Lulu, Li Lili, Feng Yizhou, Wan Xing, Wu Hao, Yang Yang. Protective effect of carrot glycosides on acute liver injury induced by concanavalin A [J]. China Modern Applied Pharmacy, 2020,37(19):2305-2310. 4. Zhang Bao Hui, Yao Xin turn, Chen Hu Fang, Zhang Chuan Ming, Lv Li Tang. Effects of different processing techniques on quality and chemical composition of Rosa roxburghii leaf tea [J]. Specialty research, 2021,43(02):57-62. 5. [IF = 7.514] Simin Feng et al."Simultaneous analysis of free phytosterols and phytosterols glycosides in rice brain by SPE/GC-MS." Food Chem. 2022 Sep;387:132742 |
474-58-8 - Reference Information
| Plant Source: | acanthopanax senticosus |
| Overview | carrot glycosides, also known as citoside, is a chemical in the form of a white powder, using high performance liquid chromatography spectrum-evaporative light scattering detection method for detection [1]. Alias carrot glycosides, sitosterol-3-o-glucoside. The proliferation of HepG2 cells was significantly inhibited by procyanidin. Mainly from Ligusticum Chuanxiong Hort, mainly containing plants: Achyranthes bidentata and Carpa seed kernel, radix dipsaci (ethyl acetate part) can be synthesized from sitosterol, also from safflower, Platycladus orientalis, Salvia miltiorrhiza, extracted from Paeonia lactiflora pall. |
| Basic information | physical properties: white powder; Shelf life: two years; Note: this product should be kept in the dark, dry and low temperature. Avoid moisture and sunlight lead to product degradation storage methods:-4°C, dark dry storage; Solubility: soluble in methanol, ethanol, DMSO and other organic solvents. |
| effect | carrot glycosides significantly inhibited the proliferation of HepG2 cells, and in a certain range (0 μg/ml- 200 μg/ml) showed concentration dependence. Compared with HepG2 not treated with carrot glycosides, the number of HepG2 cells crossing the basement membrane by 200 μg/ml carrot glycosides was significantly reduced, and the relative expression of TOPO I and TOPO II mRNA was significantly decreased. Conclusion carrot glycosides may inhibit the proliferation of HepG2 cells by down-regulating the expression of TOPO Ⅰ and TOPO Ⅱ genes, and inhibit the migration of HepG2 cells. Fig.1 inhibition of migration of HepG2 cells by citoside A, HepG2 cells not treated with citoside B, HepG2 cells treated with 200 μg/ml citoside |
| Use | carrot Glycosides can be used in scientific research, identification, pharmacological experiments, etc. |
| Method for Determination of content | a high performance liquid chromatography-evaporative light scattering detection method was used. The chromatographic column was ScienhomeinertexC18(150mm × 4.6, 5 μm), and the mobile phase was Methanol-Water (80 ∶ 20) at a flow rate of 1.0mL · min-1, the column temperature is 30 ℃; The Carrier gas is nitrogen, the gas pressure is 30.0psi, and the drift tube temperature is 80 ℃[1]. |
| extraction source | Ligusticum Chuanxiong Hort, main plants: Achyranthes bidentata and semen platycladi, radix dipsaci (ethyl acetate) can be synthesized with sitosterol, safflower, platycladus orientalis, Salvia miltiorrhiza, Paeonia lactiflora pall. |
| pharmacological effect | carrot glycoside has the effect of treating lymphoma, esophageal cancer, skin cancer, breast cancer and Periosteal sarcoma. |
| identification method | NMR;Ms |
| detection method | HPLC-ELSD: acetonitrile-water (70: 20)DMSO dissolved (for reference only) or acetonitrile: 0.2% phosphoric acid water = 95:5 wavelength: 220nm, thin layer method: Chloroform: methanol: Water = 25:5:1 or ethyl acetate: methanol: Water = 25:5:1 10% sulfuric acid ethanol color. |
| Storage Conditions | cold storage, protected from light, sealed, dry |
| reference | [1] carrot glycosides. A hundred-chain database. [Citation date: 2017.08.19] [2] Liu Xing, Xiao You Zhang. Inhibition of cell proliferation and migration and topoisomerase expression by citoside in HepG-2 cells [J/OL]. Chinese Journal of Histochemistry and cytochemistry, 2016,(05):402-405. [3] Raphanin. Chengdu de Rui Bio-Technology Co., Ltd. [Reference date: 2017.08.19] |
Last Update：2024-04-09 21:01:54
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Product Name: β-Sitosterol β-D-Glucoside Visit Supplier Webpage Request for quotationCAS: 474-58-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Daucosterol Visit Supplier Webpage Request for quotationCAS: 474-58-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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