Name | Isotetrandrine |
Synonyms | isosinomenina Isotetrandrine isosinomeninea 1-isotetrandrine O-METHYLBERBAMINE o,o'-dimethylobamegine BERBAMINE METHYL ETHER o,o'-dimethylstepholine 6,6',7,12-tetramethoxy-2,2'-dimethyl-berbama |
CAS | 477-57-6 |
Molecular Formula | C38H42N2O6 |
Molar Mass | 622.76 |
Density | 1.172 |
Melting Point | 180-182℃ |
Boling Point | 710.5±60.0 °C(Predicted) |
Specific Rotation(α) | +150.7 (c, 0.85 in CHCl3) |
Appearance | Off-white solid. |
pKa | 7.70±0.20(Predicted) |
Storage Condition | 2-8℃ |
In vitro study | Fangchi, derived from the rhizoma of S. acutum and the radix of S. tetrandra and S. acutum , has been widely used for the treatment of rheumatic arthritis. |
RTECS | NX7285000 |
Overview | Tetrandrine, also known as Tetrandrine, is an alkaloid extracted from the root block of traditional Chinese medicine Tetrandrine, it belongs to bisbenzyl isoquinoline compounds and is a new type of calcium antagonist. Studies have found that Tetrandrine can lead to DNA strand breaks, with potential genetic toxicity. A small number of patients with intravenous injection of Tetrandrine, local injection may have temporary irritation pain, pigmentation drug eruption and epistaxis tendency. Long-term medication should be regularly reviewed liver function and ECG. Liver and kidney function damage with caution. Tetrandrine is a double-group Isoi-laphane alkaloid, which is extracted from Guizhou Chinese herbal medicine. It is an optical isomer of tetrandrine. Animal experiments have confirmed that it has the effect of lowering blood pressure. |
combined treatment with Tetrandrine and aluminum citrate for pneumoconiosis. In the past 10 years, Guizhou Provincial Center for Disease Control and Prevention has treated 82 cases of pneumoconiosis with isotetrandrine (hereinafter referred to as ISO-a) and 42 cases of pneumoconiosis With Celastrol, aluminum citrate (aluminum lime) treatment of 134 cases of pneumoconiosis patients have a certain effect. A total of 40 patients with silicosis, coal worker's pneumoconiosis, foundry worker's pneumoconiosis and cement worker's pneumoconiosis were treated with the combination of ISOA and lime aluminum (no complications). The clinical treatment lasted for 1 year. | |
biological activity | isotetradrine is the active ingredient in S. acutum. |