477864-09-8
1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl
CAS: 477864-09-8
Molecular Formula: C17H23F3N2O2
477864-09-8 - Names and Identifiers
477864-09-8 - Physico-chemical Properties
| Molecular Formula | C17H23F3N2O2 |
| Molar Mass | 344.37 |
477864-09-8 - Introduction
1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl is an organic compound containing an amino group and a piperidine ring in its chemical structure. It has the following properties:
1. Appearance: White crystalline solid.
2. molecular formula: C18H25F3N2O2.
3. Molecular weight: 368.4g/mol.
4. Melting point: about 134-136°C.
5. Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl is commonly used in organic synthesis as a protecting group, which can protect the amino group under specific reaction conditions. The amino group on the piperidine ring can be subjected to various functional modifications. It also has applications in the pharmaceutical field, for example as an intermediate for the synthesis of drugs.
A common method for preparing 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl is through an amination reaction. 3-Trifluoromethylaniline and tert-butyl hydroxyformate (Boc-Cl) are first reacted to produce 3-trifluoromethylphenyl tert-butyl ester. This intermediate is then reacted with piperidine, which binds a tert-butyl group at the amino group, to give the target product 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl.
Regarding safety information, the 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl can generally be regarded as stable and safe in normal laboratory operations. However, as with all chemicals, the following points should be noted when using:
1. Avoid contact with skin and eyes, and wear appropriate protective equipment, such as laboratory gloves and goggles.
2. maintain good ventilation in the use of experimental conditions.
3. store it in a dry, cool place, avoid contact with oxygen and moisture.
4. according to the individual experimental conditions and requirements, the correct disposal and disposal of waste.
In any laboratory operation, the hazard of chemicals should be evaluated according to the actual situation, and appropriate laboratory operating procedures and safety measures should be used.
1. Appearance: White crystalline solid.
2. molecular formula: C18H25F3N2O2.
3. Molecular weight: 368.4g/mol.
4. Melting point: about 134-136°C.
5. Solubility: Soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane.
1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl is commonly used in organic synthesis as a protecting group, which can protect the amino group under specific reaction conditions. The amino group on the piperidine ring can be subjected to various functional modifications. It also has applications in the pharmaceutical field, for example as an intermediate for the synthesis of drugs.
A common method for preparing 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl is through an amination reaction. 3-Trifluoromethylaniline and tert-butyl hydroxyformate (Boc-Cl) are first reacted to produce 3-trifluoromethylphenyl tert-butyl ester. This intermediate is then reacted with piperidine, which binds a tert-butyl group at the amino group, to give the target product 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl.
Regarding safety information, the 1-Boc-4-(3-Trifluoromethyl-Phenylamino)-Piperidinetert-Butyl can generally be regarded as stable and safe in normal laboratory operations. However, as with all chemicals, the following points should be noted when using:
1. Avoid contact with skin and eyes, and wear appropriate protective equipment, such as laboratory gloves and goggles.
2. maintain good ventilation in the use of experimental conditions.
3. store it in a dry, cool place, avoid contact with oxygen and moisture.
4. according to the individual experimental conditions and requirements, the correct disposal and disposal of waste.
In any laboratory operation, the hazard of chemicals should be evaluated according to the actual situation, and appropriate laboratory operating procedures and safety measures should be used.
Last Update：2024-04-09 20:45:29
