480-54-6
Retrorsine
CAS: 480-54-6
Molecular Formula: C18H25NO6
480-54-6 - Names and Identifiers
480-54-6 - Physico-chemical Properties
| Molecular Formula | C18H25NO6 |
| Molar Mass | 351.39 |
| Density | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 208-211 °C (lit.) |
| Boling Point | 485.2°C (rough estimate) |
| Specific Rotation(α) | D18 -17.6° (c = 1.99 in ethanol) |
| Appearance | neat |
| Merck | 13,8253 |
| pKa | 12.00±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5100 (estimate) |
480-54-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 1544 |
| WGK Germany | 3 |
| RTECS | VH7525000 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
480-54-6 - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 10, Sup 7) 1987 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Retrorsine is a naturally occurring toxic pyrrolidine alkaloid. Retrorsine can bind to DNA and inhibit the proliferation of liver cells. Retrorsine can be used in the study of hepatocyte injury. |
| Cell Line: | HSEC-CYP3A4 cells |
| Concentration: | 60 μM, 120 μM , 240 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell viability. Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL. |
| Animal Model: | Male Wistar rats (180±20 g), portal branch ligation (PBL) model |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection, twice, separated by 2-week interval |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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