486422-59-7

486422-59-7 - Names and Identifiers

Name	[4-(dimethylsulfamoyl)phenyl]boronic acid
Synonyms	N,N-DIMETHYL 4-BORONOBENZENESULFONAMIDE 4-Borono-N,N-dimethylbenzenesulphonamide [4-(diMethylsulfaMoyl)phenyl]boronic acid [4-(dimethylsulfamoyl)phenyl]boronic acid 4-(N,N-Dimethylsulphonamido)benzeneboronic acid 4-(N,N-DIMETHYLSULPHONAMIDO)BENZENEBORONIC ACID [4-[(DIMETHYLAMINO)SULFONYL]PHENYL]BORONIC ACID Boronic acid, B-[4-[(diMethylaMino)sulfonyl]phenyl]- boronic acid, B-[4-[(dimethylamino)sulfonyl]phenyl]-
CAS	486422-59-7
EINECS	200-528-9
InChI	InChI=1/C8H12BNO4S/c1-10(2)15(13,14)8-5-3-7(4-6-8)9(11)12/h3-6,11-12H,1-2H3

486422-59-7 - Physico-chemical Properties

Molecular Formula	C8H12BNO4S
Molar Mass	229.06
Density	1.37±0.1 g/cm3(Predicted)
Melting Point	140-144
Boling Point	410.0±55.0 °C(Predicted)
Flash Point	201.7°C
Vapor Presure	1.86E-07mmHg at 25°C
pKa	7.39±0.10(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.579

486422-59-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant/Keep Cold

486422-59-7 - Introduction

[4-(dimethylsulfamoyl)phenyl]boronic acid is an organic boron compound with the chemical formula C8H12BNO4S. Its properties are as follows:

1. Appearance: White to light yellow solid.
2. Solubility: Soluble in many organic solvents, such as dimethyl sulfoxide, chloroform and acetonitrile.
3. melting point: about 160-165 ℃.

[4-(dimethylsulfamoyl)phenyl] The main uses of boronic acid are as follows:

1. drug synthesis: as an intermediate of benzimidazole anticancer drugs.
2. Ligands: As organoboron ligands, they form complexes with metals and are widely used in catalytic reactions.
3. chemical biology research: can be used to mediate the interaction between protein and carbohydrate or nucleic acid.

The method for preparing [4-(dimethylsulfamoyl)phenyl]boronic acid is as follows:

Under neutral or alkaline conditions, 4-(N,N-dimethylsulfonamido) benzaldehyde is prepared by reacting 4-bromomethanesulfonylbenzene with dimethylimide. Then, it reacts with triphenylboron to produce the target product [4-(dimethylsulfamoyl)phenyl]boronic acid.

Regarding safety information, the following points should be noted:

1. [4-(dimethylsulfamoyl)phenyl]boronic acid is a chemical and direct contact with skin and eyes should be avoided.
2. During operation, pay attention to prevent inhalation of gas, dust or smoke, and operate in a well-ventilated place.
3. Wear acid and alkali resistant gloves and protective glasses if necessary.
4. in case of contact, rinse immediately with plenty of water and seek medical advice.
5. The compound may be harmful to the environment, should comply with the corresponding waste disposal regulations.

Last Update：2024-04-09 20:02:46