491-54-3
4'-Methoxy-3,5,7-trihydroxyflavone
CAS: 491-54-3
Molecular Formula: C16H12O6
491-54-3 - Names and Identifiers
| Name | 4'-Methoxy-3,5,7-trihydroxyflavone |
| Synonyms | Kaemperide KAEMPFERIDE Kaempferide ARTEMISIA ANNUA 4'-methylkaempferol 3,5,7-Trihydroxy-4-methoxyflavone 4'-Methoxy-3,5,7-trihydroxyflavone Kaempferide~3,5,7-Trihydroxy-4-methoxyflavone 3,5,7-Trihydroxy-2-(4-methoxy-phenyl)-chromen-4- 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4-benzopyrone 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one 3,5,7-trihydroxy-2-(4-methoxyphenyl)-1-benzopyran-4-one |
| CAS | 491-54-3 |
| EINECS | 207-738-4 |
| InChI | InChI=1/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 |
491-54-3 - Physico-chemical Properties
| Molecular Formula | C16H12O6 |
| Molar Mass | 300.26 |
| Density | 1.538 |
| Melting Point | 156-157°C(lit.) |
| Boling Point | 543.8±50.0 °C(Predicted) |
| Flash Point | 207.1°C |
| Solubility | Soluble in hot methanol, DMSO and other solvents, insoluble in petroleum ether, ether, chloroform. |
| Vapor Presure | 1.94E-12mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Yellow |
| BRN | 305378 |
| pKa | 6.32±0.40(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.709 |
| MDL | MFCD00016771 |
| Physical and Chemical Properties | Yellow needle Crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from galangal, Equisetum, VAS, safflower, sedum sarmentosum, Lysimachia. |
491-54-3 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | KD4170000 |
| HS Code | 29329990 |
491-54-3 - Reference
| Reference Show more | 1. Li Chunna fan Bing rudder Liu Yangyang, etc. Simultaneous determination of five effective components in cyclocarya Paliurus extract by HPLC-DAD wavelength switching method [J]. Liaoning Journal of Traditional Chinese Medicine 2015(6th issue): -1285. 2. Wang Jiye, Wang Xiaoqin, Tang Yan, Zhang Bo. Network pharmacological mechanism of 4 kinds of anti vitiligo Uygur medicine based on the theory of mucus [J]. Chinese Journal of Traditional Chinese Medicine, 2018,43(09):1780-1788. 3. NI Zhunan, Tan, Ying, Yu, village, et al. Determination of total flavonol glycosides in health food [J]. Preventive Medicine 2017 29(006):P.574-578. 4. Unknown. Simultaneous determination of nine index components in cyclocarya Paliurus by high performance liquid chromatography [J]. Natural product research and development, 2017, 11(v.29):96-100. 5. Zhang Yan, Li Yuanyuan, an Xinxin, et al. Antiviral flavonoid fraction and effective chemical constituents of Shiwei [J]. Journal of Jinan University: natural science and medicine edition, 2018, 039(006):470-480. 6. Wang Wenqi, Li Yuanyuan, Wang Shuang, Zhu Yanjun, Sun Mengjia, Cai Fujie, Sun Xiaohui, Liu Qing, Zhou Honglei. Study on antiviral active components of total flavonoids from Patrinia villosa L. In vitro [J]. Shandong Science, 2020,33(05):43-50. 7. Yu Lan, Tang Hui, Chen Hanying, Wang Xiaoqin, Zhang Bo. Pharmacodynamic evaluation and mechanism of promoting zebrafish melanin production by methoxyflavone [J]. Chinese herbal medicine, 2020,51(23):6023-6034. 8. Wang, J., chen, H., wang, Y. et al. Network pharmacologic mechanisms of Vernonia antherelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes. BMC Syst Biol 11, 103 (2017). https 9. [IF=5.396] Jiachan Zhang et al."Understanding the role of extracts from sea buckthorn seed residues in anti-melanogenesis properties on B16F10 melanoma cells."Food Funct. 2018 Oct;9(10):5402-5416 10. [IF=2.048] Wang Ji Ye et al."Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes."Bmc Syst Biol. 2017 Dec;11(1):1-12 11. [IF=5.81] Jiye Wang et al."Development of a Multi-Target Strategy for the Treatment of Vitiligo via Machine Learning and Network Analysis Methods."Front Pharmacol. 2021; 12: 754175 12. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 13. [IF=3.645] Yu Zhang et al."Qualitative and quantitative analysis of Alpiniae Oxyphyllae fructus by HPLC coupled to Fourier transform-ion cyclotron resonance mass spectrometry."Journal Of Separation Science. 2022 Jan 11 14. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 15. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 |
491-54-3 - Nature
Open Data Verified Data
is a yellow needle-like crystal. The melting point was 276-278 °c. Slightly soluble in water, soluble in alkaline aqueous solution and hot ethanol, ether, acetone, ethyl acetate, chloroform and other organic solvents.
Last Update：2024-01-02 23:10:35
491-54-3 - Preparation Method
Open Data Verified Data
generally, sophorae fructus is used as a raw material for extraction. Sophorae fructus was extracted with ethanol, the extract was hydrolyzed with acid to precipitate precipitates, the precipitate was extracted with ether, and the ether extract was examined by polyamide thin layer plate (chloroform: methanol 3:1 as developing solvent), there are mainly 2 spots, imitation of polyamide thin layer chromatography conditions, polyamide column chromatography. Take the polyamide powder (60-120 mesh) llOg and load it into a polyethylene film column with a circumference of 10cm. Stir the sample into the polyamide powder lOg, draw it dry under reduced pressure, finely grind it, load it into the top of the column, and then use chloroform: methanol (3:1) was spread to the bottom of the column. The whole column has two main yellow layer bands, one in the section 17 ~ 21cm from the bottom of the column (with work), the other in the section 17 ~ 34cm from the bottom of the column (with II). The two laminas were cut and eluted with ethanol respectively. The eluate was crystallized with methanol-water to obtain yellow needle crystals, which were genistein. The eluate with Ⅱ was crystallized with chloroform-acetone for 2 times, yellow Fine-leaf crystals were obtained, which were kaempferol.
Last Update：2022-01-01 11:15:10
491-54-3 - Use
Open Data Verified Data
is a medicinal plant extract with antitussive and expectorant effects.
Last Update：2022-01-01 11:15:11
491-54-3 - Reference Information
| biological activity | Kaempferide (4 '-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4 '-methyl ether) is a natural product extracted from Kaempfera root and has a variety of biological activities, including anti-cancer, anti-inflammatory, antioxidant, antibacterial and antiviral activities. |
| uses | kaempferol has anti-cancer, anti-fertility, anti-epilepsy, anti-inflammatory, antioxidant and anti-ulcer effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: warm pain relief. Treat abdominal cold pain, stop eating, fall and damage. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: Kaempferide Visit Supplier Webpage Request for quotationCAS: 491-54-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Kaempferide Visit Supplier Webpage Request for quotationCAS: 491-54-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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