5(10)-trien-17-one,3,4-dihydroxy-estra-3
4-hydroxyestrone
CAS: 3131-23-5
Molecular Formula: C18H22O3
5(10)-trien-17-one,3,4-dihydroxy-estra-3 - Names and Identifiers
| Name | 4-hydroxyestrone |
| Synonyms | 4-HYDROXYESTRONE 4-hydroxyestrone Estrone 4-Hydroxy Impurity 1,3,5(10)-ESTRATRIEN-3,4-DIOL-17-ONE 1,3,5[10]-ESTRATRIENE-3,4-DIOL-17-ONE 5(10)-trien-17-one,3,4-dihydroxy-estra-3 3,4-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE 3,4-dihydroxyestra-1,3,5(10)-trien-17-one (9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one |
| CAS | 3131-23-5 |
| InChI | InChI=1/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11-,12-,14+,18+/m1/s1 |
5(10)-trien-17-one,3,4-dihydroxy-estra-3 - Physico-chemical Properties
| Molecular Formula | C18H22O3 |
| Molar Mass | 286.37 |
| Density | 1.241±0.06 g/cm3(Predicted) |
| Melting Point | 260-263°C |
| Boling Point | 468.2±45.0 °C(Predicted) |
| Flash Point | 93°C |
| Solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Light Brown |
| pKa | 10.06±0.40(Predicted) |
| Storage Condition | −20°C |
| Refractive Index | 1.61 |
5(10)-trien-17-one,3,4-dihydroxy-estra-3 - Risk and Safety
| WGK Germany | 3 |
| RTECS | KG7749500 |
5(10)-trien-17-one,3,4-dihydroxy-estra-3 - Introduction
4-hydroxyestrone(4-hydroxyestrone) is an estrogen that has the following properties:
1. Physical properties: 4-hydroxyestrone is a white crystalline solid with a molecular formula of C18H18O3 and a molecular weight of 282.33g/mol.
2. Physiological activity: it is one of the metabolites of natural estrogen estrone (estrone). In the human body, 4-hydroxyestrone has certain physiological activity, especially plays an important role in the development of breast cancer.
3. Application: Due to the effect of 4-hydroxyestrone on breast cancer, it is widely used in the research and diagnosis of breast cancer. In addition, 4-hydroxyestrone is also used as a biomarker for the Study of estrogen metabolism and related diseases.
4. Preparation method: 4-hydroxyestrone can be produced by metabolizing estrone in vivo or by chemical synthesis. A common synthetic method is to react estrone with an oxidizing agent, such as by oxidizing estrone with hydrogen peroxide to give 4-hydroxyestrone.
5. Safety information: As a compound, the safety of 4-hydroxyestrone depends on the specific application and dosage. When used in scientific research, it is necessary to follow the relevant laboratory practices and safety manuals. During use, attention should be paid to controlling dosage and reducing exposure to avoid potential health risks.
1. Physical properties: 4-hydroxyestrone is a white crystalline solid with a molecular formula of C18H18O3 and a molecular weight of 282.33g/mol.
2. Physiological activity: it is one of the metabolites of natural estrogen estrone (estrone). In the human body, 4-hydroxyestrone has certain physiological activity, especially plays an important role in the development of breast cancer.
3. Application: Due to the effect of 4-hydroxyestrone on breast cancer, it is widely used in the research and diagnosis of breast cancer. In addition, 4-hydroxyestrone is also used as a biomarker for the Study of estrogen metabolism and related diseases.
4. Preparation method: 4-hydroxyestrone can be produced by metabolizing estrone in vivo or by chemical synthesis. A common synthetic method is to react estrone with an oxidizing agent, such as by oxidizing estrone with hydrogen peroxide to give 4-hydroxyestrone.
5. Safety information: As a compound, the safety of 4-hydroxyestrone depends on the specific application and dosage. When used in scientific research, it is necessary to follow the relevant laboratory practices and safety manuals. During use, attention should be paid to controlling dosage and reducing exposure to avoid potential health risks.
Last Update：2024-04-10 22:29:15
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CAS: 3131-23-5
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CAS: 3131-23-5
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Email: 3008007409@qq.com
Mobile: 18021002903
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