5,6-Difluorooxindol
5,6-Difluorooxindole
CAS: 71294-07-0
Molecular Formula: C8H5F2NO
5,6-Difluorooxindol - Names and Identifiers
| Name | 5,6-Difluorooxindole |
| Synonyms | 5,6-Difluorooxindol 5,6-Difluorooxindole 5,6-DIFLUOROOXINDOLE 5,6-Difluoro-2-oxindole 5,6-Difluoro-2-oxoindole 5,6-Difluoro-2-Oxoindole 5,6-difluoroindolin-2-one 5,6-Difluoro-1,3-dihydro-2H-indol-2-one 5,6-difluoro-2,3-dihydro-1H-indol-2-one [dimethyl(3,3,4,4,4-pentafluorobutyl)silyl]oxy-dimethyl-(3,3,4,4,4-pentafluorobutyl)silane |
| CAS | 71294-07-0 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C12H20F10OSi2/c1-24(2,7-5-9(13,14)11(17,18)19)23-25(3,4)8-6-10(15,16)12(20,21)22/h5-8H2,1-4H3 |
5,6-Difluorooxindol - Physico-chemical Properties
| Molecular Formula | C8H5F2NO |
| Molar Mass | 169.13 |
| Density | 1.415±0.06 g/cm3(Predicted) |
| Melting Point | 201-202 °C(Solv: benzene (71-43-2)) |
| Boling Point | 285.3±40.0 °C(Predicted) |
| Flash Point | 91°C |
| Vapor Presure | 0.12mmHg at 25°C |
| pKa | 11.88±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.355 |
5,6-Difluorooxindol - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
5,6-Difluorooxindol - Introduction
5,6-Difluorooxindole is an organic compound with the chemical formula of C8H5F2NO, which is a derivative of indole ketone compounds.
Nature:
5,6-Difluorooxindole is a colorless crystal or white solid. It is insoluble in water at room temperature, but can be dissolved in some organic solvents, such as ethanol and dimethyl ketone. This compound has a relatively high melting and boiling point.
Use:
5,6-Difluorooxindole is widely used in organic synthesis. It can be used as an intermediate in the synthesis of pharmaceuticals, pesticides and other organic compounds. Its derivatives can also be used in the fields of biomedical research and drug development.
Preparation Method:
5,6-Difluorooxindole can be generated by the reaction of indole -2, 3-dione with hydrogen bifluoride. Specific synthetic methods include the reaction of ketoene with difluoroethanone under the catalysis of hydrofluoric acid, the reaction of ketoene with hydrofluoric acid-anhydrous hydrogen fluoride, etc.
Safety Information:
5,6-Difluorooxindole is an organic compound, and attention should be paid to its safe use. During operation, wear appropriate protective gloves and glasses to avoid skin contact and eye irritation. During storage, it should be kept in a dry, cool place, away from fire and oxidizing agents. When disposing of waste, it should be properly disposed of in accordance with local environmental regulations to prevent adverse effects on the environment and human body.
Nature:
5,6-Difluorooxindole is a colorless crystal or white solid. It is insoluble in water at room temperature, but can be dissolved in some organic solvents, such as ethanol and dimethyl ketone. This compound has a relatively high melting and boiling point.
Use:
5,6-Difluorooxindole is widely used in organic synthesis. It can be used as an intermediate in the synthesis of pharmaceuticals, pesticides and other organic compounds. Its derivatives can also be used in the fields of biomedical research and drug development.
Preparation Method:
5,6-Difluorooxindole can be generated by the reaction of indole -2, 3-dione with hydrogen bifluoride. Specific synthetic methods include the reaction of ketoene with difluoroethanone under the catalysis of hydrofluoric acid, the reaction of ketoene with hydrofluoric acid-anhydrous hydrogen fluoride, etc.
Safety Information:
5,6-Difluorooxindole is an organic compound, and attention should be paid to its safe use. During operation, wear appropriate protective gloves and glasses to avoid skin contact and eye irritation. During storage, it should be kept in a dry, cool place, away from fire and oxidizing agents. When disposing of waste, it should be properly disposed of in accordance with local environmental regulations to prevent adverse effects on the environment and human body.
Last Update：2024-04-09 02:00:47
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