5,6-Diphenyl-2-hydroxypyrazine
5,6-DIPHENYLPYRAZIN-2-OL
CAS: 18591-57-6
Molecular Formula: C16H12N2O
5,6-Diphenyl-2-hydroxypyrazine - Names and Identifiers
5,6-Diphenyl-2-hydroxypyrazine - Physico-chemical Properties
| Molecular Formula | C16H12N2O |
| Molar Mass | 248.28 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Melting Point | 225-227 °C |
| Boling Point | 492.2℃ at 760 mmHg |
| pKa | 10.55±0.60(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | Overview 5, 6-diphenyl-2-hydroxypyrazine is a pharmaceutical intermediate, which can be prepared from bibenzoyl and aminoacetamide hydrochloride in one step. It has been reported that 5, 6-diphenyl-2-hydroxypyrazine can be used to prepare IP receptor agonists (Compound I). |
5,6-Diphenyl-2-hydroxypyrazine - Synthesis method
under the protection of nitrogen, bibenzoyl (2.10g, 0.01mol), aminoacetamide hydrochloride (1.32g, 0.012mol) and NaOH(0.96g,0.024mol) were successively added into 20mL methanol solvent, heated and refluxed for 3~4h, and the reaction was completely monitored by LC-MS. The reaction solution is cooled to 0~5 ℃, then 12N HCl(1.25mL) solution is added dropwise, and after stirring the reaction solution at room temperature for 30min, 1g of sodium bicarbonate and 13mL of water are added, the reaction solution is filtered, the solid is washed with water (5mL) and methanol (5mL) respectively, and 2.20g of white solid 5,6-diphenyl -2-hydroxypyrazine is obtained by vacuum drying, the yield is 88.7%, ESI-MS: M/z = 249.2(M H).
Last Update：2024-04-10 22:29:15
5,6-Diphenyl-2-hydroxypyrazine - Reference Information
| Overview | 5, 6-diphenyl-2-hydroxypyrazine is a pharmaceutical intermediate, which can be prepared from bibenzoyl and aminoacetamide hydrochloride in one step. It has been reported that 5, 6-diphenyl-2-hydroxypyrazine can be used to prepare IP receptor agonists (Compound I). |
| synthesis method | under the protection of nitrogen, bibenzoyl (2.10g, 0.01mol), aminoacetamide hydrochloride (1.32g, 0.012mol) and NaOH(0.96g,0.024mol) are successively added into 20mL methanol solvent, heated and refluxed for 3-4h, and the raw material reaction is complete through LC-MS monitoring reaction. The reaction solution is cooled to 0~5 ℃, then 12N HCl(1.25mL) solution is added dropwise, and after stirring the reaction solution at room temperature for 30min, 1g of sodium bicarbonate and 13mL of water are added, the reaction solution is filtered, the solid is washed with water (5mL) and methanol (5mL) respectively, and 2.20g of white solid 5,6-diphenyl -2-hydroxypyrazine is obtained by vacuum drying, the yield is 88.7%, ESI-MS: M/z = 249.2(M H). |
Last Update：2024-04-09 21:01:54
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