5,6-difluoro-1H-indole
5,6-Difluoroindole
CAS: 169674-01-5
Molecular Formula: C8H5F2N
5,6-difluoro-1H-indole - Names and Identifiers
| Name | 5,6-Difluoroindole |
| Synonyms | 5,6-Difluoroindole 5,6-DIFLUOROINDOLE 5,6-Difluoro-1H-indole 5,6-difluoro-1H-indole 1H-Indole,5,6-difluoro- 1H-Indole,5,6-difluoro-(9CI) 5,6-difluoro-1H-indole-2-carboxylic acid |
| CAS | 169674-01-5 |
| InChI | InChI=1/C9H5F2NO2/c10-5-1-4-2-8(9(13)14)12-7(4)3-6(5)11/h1-3,12H,(H,13,14) |
5,6-difluoro-1H-indole - Physico-chemical Properties
| Molecular Formula | C8H5F2N |
| Molar Mass | 153.13 |
| Density | 1.388±0.06 g/cm3(Predicted) |
| Boling Point | 264.5±20.0 °C(Predicted) |
| Flash Point | 212.3°C |
| Vapor Presure | 4.59E-08mmHg at 25°C |
| pKa | 15.56±0.30(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.661 |
5,6-difluoro-1H-indole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| Hazard Class | IRRITANT |
5,6-difluoro-1H-indole - Introduction
5,6-difluoroindole (5,6-difluoroindole) is an organic compound. Its chemical formula is C8H5F2N and its molecular weight is 145.13.
Nature:
5,6-difluoroindole is a colorless crystalline substance with strong hydrogen bonding and π-π stacking. It is readily soluble in organic solvents such as ethanol, chloroform and dichloromethane, but insoluble in water. The compound has a lower melting point and boiling point, as well as greater stability.
Use:
5,6-difluoroindole is widely used in organic synthesis as a starting material and intermediate. It can be used to synthesize drugs, pesticides and chemicals. In addition, it is also used to prepare materials with special photoelectric properties.
Method:
5,6-difluoroindole is generally synthesized by the method of fluorinating indole. A common synthetic method is to react indole with a fluorinating agent, such as ammonium bifluoride, in the presence of hydrofluoric acid to give 5,6-difluoroindole.
Safety Information:
There are very limited safety and toxicity data regarding 5,6-difluoroindole. Attention should be paid to the toxicity and harmfulness of the compound, and direct contact with the skin and inhalation of its dust should be avoided. During use, appropriate protective measures should be taken, such as wearing gloves, protective glasses and maintaining good ventilation.
Nature:
5,6-difluoroindole is a colorless crystalline substance with strong hydrogen bonding and π-π stacking. It is readily soluble in organic solvents such as ethanol, chloroform and dichloromethane, but insoluble in water. The compound has a lower melting point and boiling point, as well as greater stability.
Use:
5,6-difluoroindole is widely used in organic synthesis as a starting material and intermediate. It can be used to synthesize drugs, pesticides and chemicals. In addition, it is also used to prepare materials with special photoelectric properties.
Method:
5,6-difluoroindole is generally synthesized by the method of fluorinating indole. A common synthetic method is to react indole with a fluorinating agent, such as ammonium bifluoride, in the presence of hydrofluoric acid to give 5,6-difluoroindole.
Safety Information:
There are very limited safety and toxicity data regarding 5,6-difluoroindole. Attention should be paid to the toxicity and harmfulness of the compound, and direct contact with the skin and inhalation of its dust should be avoided. During use, appropriate protective measures should be taken, such as wearing gloves, protective glasses and maintaining good ventilation.
Last Update：2024-04-09 21:54:55
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CAS: 169674-01-5
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