5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE
5,7-dihydroxy-2-phenyl-2,3-dihydro-4H-chromen-4-one
CAS: 480-39-7;68745-38-0
Molecular Formula: C15H12O4
5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE - Names and Identifiers
5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE - Physico-chemical Properties
| Molecular Formula | C15H12O4 |
| Molar Mass | 256.25 |
| Density | 1.386±0.06 g/cm3(Predicted) |
| Melting Point | 202 °C |
| Boling Point | 511.1±50.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.9 in Me2CO)-45.3 |
| Flash Point | 203.3°C |
| Solubility | Soluble in hot methanol and DMSO, insoluble in petroleum ether and chloroform. |
| Vapor Presure | 1.85E-11mmHg at 25°C |
| Appearance | Colorless crystal |
| pKa | 7.50±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.661 |
| MDL | MFCD06858345 |
| Physical and Chemical Properties | Soluble in hot methanol, DMSO, insoluble in petroleum ether, chloroform. Source of Swiss five needle pine (PIRA), the heartwood of the cherry tree |
5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE - Reference
| Reference Show more | 1. Sun Jingwei, Shao Ming. Protective effect and mechanism of high fat diet induced nonalcoholic fatty liver disease in rats [J]. Sichuan traditional Chinese medicine 2019v.37;No.433(12):54-58. 2. Cheng Jian-an, Feng Lei, Yu Yuan. Determination of four components in alcohol extract of pentrazol by HPLC [J]. China Science and Technology of traditional Chinese medicine 2019v.26(04):58-60. 3. Zhou Yunhong, Li Xilin, Liu Guobin. Study on quality control of borneol in Zizhu gel [J]. China Science and Technology of traditional Chinese medicine, 2019, v.26(04):55-58. 4. Chang Guanhua, thin Yingyi, Cui Jie, Xu Lulu, Zhao Ziyan, Wang Wenquan, Hou Junling. Analysis of the main chemical components of the aerial parts of licorice based on UPLC-Q-Exactive Orbitrap-MS [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(06):1449-1459. 5. [IF = 7.808] Jianhua Li et al."Production of plant-specific flavones baicalein and scutellarein an engineered E. coli from available phenylalaine and tyrosine." Metab Eng. 2019 Mar;52:124 6. [IF = 2.896] Jun-Qing Zhang et al."Simultaneous quantification of seventeen bioactive components in rhizome and aerial parts of Alpinia officinarum Hance using LC-MS/MS."Anal Methods-Uk. 2015 Jun;7(12):4919-4926 7. [IF=5.279] Yang Lu et al."Interconversion and Acrolein-Trapping Capacity of Cardamonin/Alpinetin and Their Metabolites In Vitro and In Vivo."J Agr Food Chem. 2021;69(40):11926-11936 8. [IF=4.192] Qiangqiang Li et al."Bee Pollen Extracts Modulate Serum Metabolism in Lipopolysaccharide-Induced Acute Lung Injury Mice with Anti-Inflammatory Effects."J Agr Food Chem. 2019;67(28):7855-7868 9. [IF=6.529] Lijun Song et al.Establishment of a rotavirus-infected zebrafish model and its application in drug screening.Biomed Pharmacother. 2022 Jan;145:112398 10. [IF=4.412] Haifan Liu et al."Pharmacokinetics, Prostate Distribution and Metabolic Characteristics of Four Representative Flavones after Oral Administration of the Aerial Part of Glycyrrhiza uralensis in Rats."MOLECULES. 2022 Jan;27(10):3245 |
5,7-DIHYDROXY-2-PHENYL-CHROMAN-4-ONE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a multifunctional flavonoid molecule in the pharmaceutical industry. It has many pharmaceutical activities, such as antibacterial, anti-inflammatory, antioxidant and anti-cancer activities. |
| Cell Line: | RBL-2H3 cells |
| Concentration: | 5, 10, 25, 50, 100 or 200 µM |
| Incubation Time: | 24 hours |
| Result: | Decreased cell viability by ∼50% at ≥ 100 µM. Showed 75% cell viability at lower concentrations. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has certain antioxidant and anti-inflammatory effects. |
Last Update：2024-04-09 20:13:35
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Spot supply
Product Name: rac-Pinocembrin Visit Supplier Webpage Request for quotationCAS: 68745-38-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Pinocembrin Visit Supplier Webpage Request for quotationCAS: 480-39-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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