5,7-Dichloro-8-oxychinolin
5,7-Dichloro-8-hydroxyquinoline
CAS: 773-76-2
Molecular Formula: C9H5Cl2NO
5,7-Dichloro-8-oxychinolin - Names and Identifiers
| Name | 5,7-Dichloro-8-hydroxyquinoline |
| Synonyms | Chloroxine 5,7-Dichloroxine 5,7-Dichlorooxine 5,7-Dichloro-8-hydroxy 5,7-dichloro-8-quinolino 5,7-Dichloro-8-quinolinol 5,7-Dichloro-8-oxychinolin 5,7-Dichloro-8-oxyquinoline 5,7-Dichlor-8-hydroxychinolin 5,7-Dichloro-8-hydroquinoline 5,7-Dichloro-8-hydroxyquinolin 5,7-Dichloro-8-hydroxyquinoline 5,7-Dichloro-8-hydroxy-quinoline 5,7-Dichloro-8-hydroxy quinoline |
| CAS | 773-76-2 |
| EINECS | 212-258-3 |
| InChI | InChI=1/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H |
5,7-Dichloro-8-oxychinolin - Physico-chemical Properties
| Molecular Formula | C9H5Cl2NO |
| Molar Mass | 214.05 |
| Density | 1.3320 (rough estimate) |
| Melting Point | 178-180 °C (lit.) |
| Boling Point | 305.47°C (rough estimate) |
| Solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, H |
| Appearance | Bright light brown powder |
| Color | Light beige |
| Merck | 14,2175 |
| BRN | 153606 |
| pKa | 2.30±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Light Sensitive |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00006786 |
| Physical and Chemical Properties | Colorless or yellowish needle-like crystals. Melting point 180-181 °c. Soluble in benzene, acetone, ether, carbon disulfide, ethanol and concentrated sulfuric acid, insoluble in water, soluble in sodium hydroxide, potassium hydroxide yellow solution. |
| Use | For medicine, pesticide |
| In vitro study | By using the Jouyban-Acree model, the Chloroxine solubility is well correlated obtaining RAD values lower than 3.64% and RMSD values lower than 8.82 × 10 −6 . Chloroxine is preferentially solvated by water for the studied mixtures in water-rich compositions; while within intermediate and co-solvent-rich compositions, Chloroxine is preferentially solvated by DMSO (DMF, NMP or 1,4-dioxane) in DMSO (DMF, NMP or 1,4-dioxane) + water mixtures. It is shown that the change in solvent-solvent interaction energy accounted by cavity term governed the solubility variation of Chloroxine in all aqueous mixtures. |
5,7-Dichloro-8-oxychinolin - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S25 - Avoid contact with eyes. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| RTECS | VC5350000 |
| TSCA | Yes |
| HS Code | 29334900 |
5,7-Dichloro-8-oxychinolin - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Chloroxine is a synthetic antibacterial compound added to shampoo to effectively treat dandruff and seborrheic dermatitis. |
| Target | Bacterial |
| Use | as analytical reagent, chelating extractant. used in the synthesis of medicines and pesticides |
| production method | is obtained by chlorination of 8-hydroxyquinoline. 10g of 8-Hydroxyquinoline was dissolved in 100g of glacial acetic acid and then passed through chlorine until the solution became golden yellow. The reactant was poured into 1 liter of water to precipitate 5g of 7-dichloro-8-hydroxyquinoline, which was filtered and recrystallized from 200ml of acetone to obtain a finished product. |
Last Update：2024-04-10 22:29:15
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