5,7-difluoro-2,3-dihydro-1H-inden-1-one
5,7-difluoro-2,3-dihydro-1H-inden-1-one
CAS: 84315-25-3
Molecular Formula: C9H6F2O
5,7-difluoro-2,3-dihydro-1H-inden-1-one - Names and Identifiers
| Name | 5,7-difluoro-2,3-dihydro-1H-inden-1-one |
| Synonyms | 5,7-Difluoro-1-indanone 5,7-difluoro-1-indanone 5,7-Difluoroindan-1-one 5,7-Difluoro-2,3-dihydroinden-1-one 5,7-Difluoro-2,3-dihydro-1H-inden-1-one 5,7-difluoro-2,3-dihydro-1H-inden-1-one 5,7-Difluoro-2,3-dihydro-1H-indene-1-one 1H-inden-1-one, 5,7-difluoro-2,3-dihydro- 1H-Inden-1-one, 5,7-difluoro-2,3-dihydro- |
| CAS | 84315-25-3 |
| InChI | InChI=1/C9H6F2O/c10-6-3-5-1-2-8(12)9(5)7(11)4-6/h3-4H,1-2H2 |
| InChIKey | XWZGNWCKXLECBO-UHFFFAOYSA-N |
5,7-difluoro-2,3-dihydro-1H-inden-1-one - Physico-chemical Properties
| Molecular Formula | C9H6F2O |
| Molar Mass | 168.14 |
| Density | 1.362g/cm3 |
| Melting Point | 80-84 °C |
| Boling Point | 251.96°C at 760 mmHg |
| Flash Point | 95.924°C |
| Water Solubility | Sparingly soluble in water 0.081 g/L 25°C. |
| Vapor Presure | 0.02mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.537 |
5,7-difluoro-2,3-dihydro-1H-inden-1-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| WGK Germany | 3 |
5,7-difluoro-2,3-dihydro-1H-inden-1-one - Introduction
5,7-difluoro-2,3-dihydro-1H-inden-1-one is an organic compound with the chemical formula C9H5F2O. It is a white crystal or crystalline powder with a special smell.
One of the main uses of this compound is as a pharmaceutical intermediate. It can be used to synthesize biologically active compounds, such as drugs, pesticides and dyes. It can also be used as a catalyst and solvent in organic synthesis.
The preparation method of 5,7-difluoro-2,3-dihydro-1H-inden-1-one is usually obtained by fluorination reaction of aromatic carbonyl compounds. For example, hydrogen fluoride and a fluorinating reagent such as difluoroboric acid can be used to carry out the reaction by hydrogen bond cleavage and nucleophilic substitution reaction on the aromatic ketone ring.
When handling 5,7-difluoro-2,3-dihydro-1H-inden-1-one, attention should be paid to its safe use. It is a combustible and may burn when it encounters a source of fire. Contact with strong oxidants, strong acids and strong bases should be avoided to avoid dangerous reactions. During use and storage, care should be taken to avoid inhalation, contact with skin and entry into eyes. Appropriate personal protective measures such as goggles, gloves and respirators should be taken when necessary.
One of the main uses of this compound is as a pharmaceutical intermediate. It can be used to synthesize biologically active compounds, such as drugs, pesticides and dyes. It can also be used as a catalyst and solvent in organic synthesis.
The preparation method of 5,7-difluoro-2,3-dihydro-1H-inden-1-one is usually obtained by fluorination reaction of aromatic carbonyl compounds. For example, hydrogen fluoride and a fluorinating reagent such as difluoroboric acid can be used to carry out the reaction by hydrogen bond cleavage and nucleophilic substitution reaction on the aromatic ketone ring.
When handling 5,7-difluoro-2,3-dihydro-1H-inden-1-one, attention should be paid to its safe use. It is a combustible and may burn when it encounters a source of fire. Contact with strong oxidants, strong acids and strong bases should be avoided to avoid dangerous reactions. During use and storage, care should be taken to avoid inhalation, contact with skin and entry into eyes. Appropriate personal protective measures such as goggles, gloves and respirators should be taken when necessary.
Last Update：2024-04-09 02:00:48
