Molecular Formula | C15H10O4 |
Molar Mass | 254.24 |
Density | 1.443 |
Melting Point | 227-233 °C (lit.) |
Storage Condition | Room Temprature |
In vitro study | LC3-mHTT-IN-AN2 (10, 50, 100, and 300 nM) reduces the levels of mHTT in an allele-selective manner in cultured HD mouse neurons. |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
Hazard Class | IRRITANT |
biological activity | LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linking Compound, LC3-mHTT-IN-AN2 with mutant huntingtin (mHTT) interacts with LC3B, but not with wtHTT or an unrelated control protein. LC3-mHTT-IN-AN2 decreases mHTT levels in neurons of Huntington's disease (HD) mice in an allele-selective manner. |
Target | mHTT-LC3 Linker Compound |