5,8-Dimethoxypsoralen
Isopimpinellin
CAS: 482-27-9
Molecular Formula: C13H10O5
5,8-Dimethoxypsoralen - Names and Identifiers
5,8-Dimethoxypsoralen - Physico-chemical Properties
| Molecular Formula | C13H10O5 |
| Molar Mass | 246.22 |
| Density | 1.352±0.06 g/cm3(Predicted) |
| Melting Point | 150-151°C |
| Boling Point | 448.7±45.0 °C(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | Yellow powder |
| Color | Light yellow to Yellow to Green |
| Maximum wavelength(λmax) | ['268nm(MeOH)(lit.)'] |
| BRN | 262337 |
| Storage Condition | Sealed in dry,2-8°C |
| MDL | MFCD00017407 |
| Physical and Chemical Properties | Pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Saxifraga, Cnidium. |
5,8-Dimethoxypsoralen - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R28 - Very Toxic if swallowed |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS | LV1049200 |
| HS Code | 2932202000 |
5,8-Dimethoxypsoralen - Reference
| Reference Show more | 1. Li Minmin, Hu Junhua, He Lei, et al. Isolation and identification of active constituents from extracts of Angelica sinensis against pathogenic fungi of citrus [J]. Journal of fruit Science, 2012(05):900-904. 2. Guo Xiaoxia, Li Donghua, Ma Xiao, etc. Determination of four chemical constituents in radix angelicae pubescentis decoction pieces [J]. Modern Chinese medicine, 2020, 022(002):266-270. 3. Peng Wen-hui, Zhao Xi-Juan, Chen Xi, Zhang Yao-Hai, Wang Cheng-Qiu, Zhao Qi-Yang, jiao bi-Ning. Rapid screening of bioactive components in lemon fruit by ultra performance liquid chromatography-quadrupole-Time of Flight high resolution mass spectrometry [J]. Food and Fermentation Industry, 2021,47(04):222-230 235-237. 4. Ammonadi, Abdorreza, et al. "Enzyme-assisted extraction and ionic liquid-based dispersion liquid-liquid micro extraction follow by high-performance liquid chromatography for determination of patent in apple justice and method optimization central co 5. [IF = 3.645] Heyuan Qiu et al."Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave-assisted extraction coupled with high-speed counter-current chromatography."J Sep Sci. 2012 Apr;35(7):901-906 6. [IF=2.896] Junmei Li et al."Microwave-assisted extraction and ionic liquid-based dispersive liquid-liquid microextraction followed by HPLC for determination of trace components in a Langdu preparation."Anal Methods-Uk. 2016 Jun;8(26):5218-5227 7. [IF=6.576] Li Guijie et al."Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice."Front Nutr. 2021 Jun;0:329 |
5,8-Dimethoxypsoralen - Reference Information
| biological activity | isopimpinelin is an orally active compound isolated from the roots of Pimpinella saxifage. Isopimpinelin blocks the formation of DNA adducts and the development of skin tumors by 7,12-dimethybenz [a]anthracene. Isopimpinelin has activity against leishmaniasis. |
| Animal Model: | Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study. |
| Dosage: | 35–150 mg/kg. |
| Administration: | Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone). |
| Result: | Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively |
| Use | for content determination/identification/pharmacological experiment used as reference substance of traditional Chinese medicine |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Isopimpinellin Visit Supplier Webpage Request for quotationCAS: 482-27-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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