5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde
CAS: 881674-56-2
Molecular Formula: C11H8FNO
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde - Names and Identifiers
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde - Physico-chemical Properties
| Molecular Formula | C11H8FNO |
| Molar Mass | 189.19 |
| Density | 1.270±0.06 g/cm3(Predicted) |
| Melting Point | 133 °C |
| Boling Point | 370.6±32.0 °C(Predicted) |
| Solubility | Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Light Brown to Brown |
| pKa | 14.77±0.50(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde - Reference Information
| Use | 5-(2-fluorophenyl)-1H-pyrrol-3-carbaldehyde acts as a potassium competitive acid blocker (P-CAB) in the synthesis of pyrrole derivatives. potassium competitive acid blockers for the treatment of acid-related diseases, such as gastric ulcer, duodenal ulcer, reflux esophagitis |
| Application | 5-(2-fluorophenyl)-1H-pyrrol-3-carboxaldehyde (1-[(2S)-2-pyrrolidinecarbonyl]-pyrrolidine) is a potassium competitive acid blocker for the treatment of acid-related diseases, gastric ulcers, duodenal ulcer, reflux esophagitis, etc. |
| preparation | with 1H pyrrole as raw material, after protection by N-alkylation of triisopropylchlorosilane, 3-aldehyde-1-H pyrrole was obtained by the reaction with the villsmeier reagent and then N-bromosuccinimide (NBS). Bromination and 2-fluorophenylboronic acid were carried out Suzuki coupling reaction to obtain 5-(2-fluorophenyl) pyrrol-3-carboxaldehyde crude product, which was refined with toluene. The overall yield was 35.5%. |
Last Update：2024-04-09 19:05:15
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