5-(3-Chlorophenyl)pyridin-2-amine

5-(3-Chlorophenyl)pyridin-2-amine - Names and Identifiers

Name	5-(3-Chlorophenyl)-2-pyridinamine
Synonyms	AKOS BAR-0873 4-(6-Chloropyridin-2-yl)aniline 5-(3-Chlorophenyl)-2-pyridinamine 5-(3-CHLOROPHENYL)-2-PYRIDINAMINE 5-(3-CHLOROPHENYL)PYRIDIN-2-AMINE 5-(3-Chlorophenyl)pyridin-2-amine 2-AMino-5-(3-chlorophenyl)pyridine 2-Pyridinamine, 5-(3-chlorophenyl)-
CAS	893738-14-2
InChI	InChI=1/C11H9ClN2/c12-10-3-1-2-8(6-10)9-4-5-11(13)14-7-9/h1-7H,(H2,13,14)

5-(3-Chlorophenyl)pyridin-2-amine - Physico-chemical Properties

Molecular Formula	C11H9ClN2
Molar Mass	204.66
Density	1.261
Boling Point	355.43°C at 760 mmHg
Flash Point	168.758°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.635

5-(3-Chlorophenyl)pyridin-2-amine - Introduction

5-(3-Chlorophenyl)-2-pyridinamine is an organic compound with the chemical formula C11H9ClN2 and a molecular weight of 208.65g/mol.

Its properties include:
1. appearance: colorless to light yellow crystal.
2. solubility: soluble in some organic solvents such as chloroform and dichloromethane, insoluble in water.
3. melting point: about 134-137 degrees Celsius.

The main use of 5-(3-Chlorophenyl)-2-pyridinamine is as a pharmaceutical intermediate and a starting material for organic synthesis. It can be used in the synthesis of various drugs, such as antiepileptic drugs, antipsychotics and beta-blockers.

The method of preparing 5-(3-Chlorophenyl)-2-pyridinamine can be carried out by the following steps:
1. Pyridine and bromoacetate are reacted to give 2-bromoethylpyridine.
2. reacting 2-bromoethylpyridine with aniline to generate 5-(3-aminophenyl)-2-bromoethylpyridine.
3. Finally, 5-(3-aminophenyl)-2-bromoethylpyridine was reacted with silver chloride in the presence of sodium hydroxide to give 5-(3-Chlorophenyl)-2-pyridinamine.

Regarding safety information, 5-(3-Chlorophenyl)-2-pyridinamine is an organic compound with certain dangers. It may be irritating to the eyes, skin and respiratory system and should be avoided by contact or inhalation. Appropriate protective measures, such as protective gloves, goggles and respiratory protection, should be taken during use or handling. In addition, during storage and handling, keep away from fire and oxidant to avoid harmful gases.

Last Update：2024-04-09 21:00:56