| Name | Amitriptyline |
| Synonyms | Amitriptyline 5-(3-Dimethylpropylidene)dibenzo(a,d)(1,4)cycloheptadiene 5-(3'-Dimethylaminopropylidene)-dibenzo-(a,d)(1,4)-cycloheptadiene 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene 5-(gamma-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene |
| CAS | 50-48-6 |
| EINECS | 200-041-6 |
| Molecular Formula | C20H23N |
| Molar Mass | 277.4 |
| Density | 0.9415 (rough estimate) |
| Melting Point | 196-197°C |
| Boling Point | 410.26°C (rough estimate) |
| Water Solubility | 9.7 mg/mL |
| pKa | 9.4(at 25℃) |
| Refractive Index | 1.7500 (estimate) |
| Physical and Chemical Properties | Bioactive Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant with analgesic effect and is widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki values of 3.45 nM and 13.3 nM, respectively. Amitriptyline can also inhibit histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor, corresponding Ki values are 0.5 nM, 7.31 nM, 235 nM and 287 nM respectively. The product is gelatinous. |
| Use | Introduction Amitriptyline trade name Elavil, is one of the most widely used painkillers. Amitriptyline can treat many mental disorders, including major depression and anxiety, and sometimes it is also used to treat mental illness, attention deficit hyperactivity disorder (ADHD, ADHD) and bipolar disorder. Amitriptyline can also prevent migraine and treat fibromyalgia and postherpetic neuralgia. |
| Hazard Class | IRRITANT |
| Raw Materials | Phenylacetic acid Hydrochloric acid Hydrogen 3-Chloro-1-(N,N-dimethyl)propylamine Phthalic anhydride |
| Downstream Products | Amitriptyline hydrochloride |