5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-Pyridinamine - Names and Identifiers
Name | 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine
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Synonyms | 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (6-amino- 2-AMINO-4-(TRIFLUOROMETHYL) PYRIDINE-5-BORONIC ACID PINACOL ESTER 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridin-2-amine 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-Pyridinamine 4-(trifluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboroloan-2-yl)pyridin-2-amine 2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)- 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (6-amino-4-(trifluoromethyl)pyridin-3-yl)boronate
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CAS | 944401-57-4
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InChI | InChI=1S/C12H16BF3N2O2/c1-10(2)11(3,4)20-13(19-10)8-6-18-9(17)5-7(8)12(14,15)16/h5-6H,1-4H3,(H2,17,18) |
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-Pyridinamine - Physico-chemical Properties
Molecular Formula | C12H16BF3N2O2
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Molar Mass | 288.07 |
Density | 1.23 |
Boling Point | 375.0±42.0 °C(Predicted) |
Water Solubility | Slightly soluble in water. |
pKa | 4.83±0.37(Predicted) |
Storage Condition | 2-8°C(protect from light) |
MDL | MFCD12923420 |
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-Pyridinamine - Introduction
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine is an organic compound with the chemical formula C11H13BF3N2O2.
Nature:
-Appearance: 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine is a white to yellowish solid.
-Melting point: about 140-144°C.
-Solubility: Good solubility in common organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane.
Use:
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine is an important organic boron reagent, which can be used in various chemical reactions, such as Suzuki coupling reaction, Stille coupling reaction and Sonogashira coupling reaction.
-It can also be used for catalytic reactions in organic synthesis and the synthesis of functional materials.
Method:
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine is usually structurally identified by nuclear magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR) and other techniques. The preparation generally involves carrying out a substitution reaction on pyridine, followed by reaction with a trifluoromethyl borate to give the target compound.
Safety Information:
Safety information on 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)-2-pyridinamine is currently limited, so it needs to be used, stored and handled under reasonable protective conditions.
Last Update:2024-04-10 22:29:15