5-(4-Hydroxybenzyl)-2,4-thiazolidinedione - Names and Identifiers
Name | 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione
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Synonyms | Pioglitazone Impurity 15 Pioglitazone M1 Metabolite Pioglitazone Metabolite M1 Pioglitazone degradation impurities 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione 5-(4-Hydroxybenzyl)-2,4-thiazolidinedione 5-(4-Hydroxybenzyl)-1,3-thiazolidine-2,4-dione 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)methyl]- 2,4-Thiazolidinedione, 5-[(4-hydroxyphenyl)Methyl]- 2,4-Dioxo-5-(4-hydroxybenzyl)-1,3-thiazolidine, 4-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]phenol
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CAS | 74772-78-4
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InChI | InChI=1/C10H9NO3S/c12-7-3-1-6(2-4-7)5-8-9(13)11-10(14)15-8/h1-4,8,12H,5H2,(H,11,13,14) |
5-(4-Hydroxybenzyl)-2,4-thiazolidinedione - Physico-chemical Properties
Molecular Formula | C10H9NO3S
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Molar Mass | 223.25 |
Density | 1.450±0.06 g/cm3(Predicted) |
Melting Point | 145-147°C |
Boling Point | 471.5±18.0 °C(Predicted) |
Flash Point | 238.965°C |
Vapor Presure | 0mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Light yellow to Light red |
pKa | 6.38±0.50(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.657 |
MDL | MFCD00754499 |
5-(4-Hydroxybenzyl)-2,4-thiazolidinedione - Introduction
5-(4-Hydroxybenzyl)thiazolidine-2,4-dione is an organic compound whose chemical formula is C11H11NO3S. The following is a description of its nature, use, formulation and safety information:
Properties: 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione is a white crystalline solid with a special phenolic fragrance. It is less soluble in water, but soluble in organic solvents such as alcohols and ethers.
Use: The compound is widely used in the field of medicine. It has anti-diabetic, antioxidant and antibacterial activities. It is used as a treatment for type 2 diabetes and regulates blood sugar levels by improving insulin resistance. In addition, it also shows potential applications in anti-tumor and anti-inflammatory therapy.
Preparation Method: 5-(4-Hydroxybenzyl)thiazolidine-2,4-dione can be prepared by a synthetic method. A common method of preparation is the reaction of 4-hydroxybenzyl bromide with thiazolidine-2, 4-dione under basic conditions.
Safety information: There are few safety studies on this compound. However, as a chemical substance, you should still pay attention to safe operation and avoid direct contact with skin and eyes. Wear appropriate protective equipment, such as lab gloves and goggles, when handling or handling the compound. In addition, follow proper laboratory practices and disposal methods. Before using this compound, it is advisable to read the relevant safety data sheets for more information on its safety.
Last Update:2024-04-09 21:32:43