5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine

5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine - Names and Identifiers

Name	5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine
Synonyms	5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine Pyrimidine, 5-(bromomethyl)-2-(trifluoromethyl)- Pyrimidine, 5-(bromomethyl)-2-(trifluoromethyl)- (9CI)
CAS	198404-35-2

5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine - Physico-chemical Properties

Molecular Formula	C6H4BrF3N2
Molar Mass	241.01
Storage Condition	Room Temprature

5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine - Introduction

5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine is an organic compound with the chemical formula C6H4BrF3N2. It has the form of a solid with the appearance of white to yellow crystals.

Nature:
-Solubility: 5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine is soluble in some organic solvents, such as dichloromethane, dimethyl sulfoxide and ethanol.
-Melting point: about 106-108°C.
-Stable in nature: It is relatively stable at room temperature, but sensitive to light and high temperature.

Use:
- 5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine can be used as an intermediate in organic synthetic compounds.
-It can be used to synthesize drugs in the field of medicine, such as antiviral drugs and anti-cancer drugs.

Preparation Method:
The preparation method of 5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine is relatively complicated and is usually synthesized by multi-step synthesis. One of the common synthetic methods is:
1. First, 2,4-dichloro -5-cyanomethylpyrimidine is used as starting material and reacts with trifluoromethanesulfonyl chloride to generate 2,4-dichloro -5-(trifluoromethyl) pyrimidine.
2. Then, 2,4-dichloro -5-(trifluoromethyl)pyrimidine is reacted with bromoethanol, and 5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine is obtained by dechlorination and deoxygenation.

Safety Information:
- 5-(Bromomethyl)-2-(trifluoromethyl)pyrimidine is an organic solvent and should be operated in a well-ventilated place.
-It may cause irritation to the eyes, respiratory tract and skin, so take appropriate protective measures when exposed.
-During use and storage, avoid contact with oxidants and strong acids to avoid unsafe chemical reactions.
-When handling the compound, the relevant safe handling and handling procedures should be followed.

Last Update：2024-04-09 21:01:54