5-(Hydroxymethyl)isothiazole
1,2-thiazol-5-ylmethanol
CAS: 1710-66-3
Molecular Formula: C4H5NOS
5-(Hydroxymethyl)isothiazole - Names and Identifiers
| Name | 1,2-thiazol-5-ylmethanol |
| Synonyms | 5-Isothiazolemethanol 5-Isothiazolylmethanol Isothiazole-5-methanol 1,2-thiazol-5-ylmethanol (isothiazol-5-yl)methanol 5-(Hydroxymethyl)isothiazole |
| CAS | 1710-66-3 |
| InChI | InChI=1/C4H5NOS/c6-3-4-1-2-5-7-4/h1-2,6H,3H2 |
5-(Hydroxymethyl)isothiazole - Physico-chemical Properties
| Molecular Formula | C4H5NOS |
| Molar Mass | 115.15 |
| Density | 1.339±0.06 g/cm3(Predicted) |
| Boling Point | 135.8±22.0 °C(Predicted) |
| Flash Point | 35.9°C |
| Vapor Presure | 5.66mmHg at 25°C |
| pKa | 13.61±0.10(Predicted) |
| Refractive Index | 1.594 |
5-(Hydroxymethyl)isothiazole - Introduction
1,2-thiazol-5-ylmethanol is an organic compound with the following properties:
1. Appearance: 1,2-thiazol-5-ylmethanol is a yellow crystalline solid.
2. Solubility: It is well soluble in water and soluble in organic solvents such as alcohols and ethers.
3. Chemical properties: 1,2-thiazol-5-ylmethanol is a weak acid, can react with strong alkali to generate the corresponding salt.
The application of 1,2-thiazol-5-ylmethanol mainly includes the following aspects:
1. Peroxide stabilizer: It is widely used as a peroxide stabilizer in tire rubber to extend the life of rubber products during service.
2. Metal corrosion inhibitor: Because it can form a stable complex with the metal surface, it is used as a metal corrosion inhibitor to delay the corrosion rate of the metal.
3. Osteogenic drugs: 1,2-thiazol-5-ylmethanol has the effect of promoting bone growth and repair, so it is used in the field of orthopedics.
The preparation method of 1,2-thiazol-5-ylmethanol mainly includes:
1. Sulfation of isothiazole: by reacting isothiazole with sulfuric acid, the sulfate of 1,2-thiazol-5-ylmethanol is obtained, and then 1,2-thiazol-5-ylmethanol is obtained by reduction reaction.
2. Condensation reaction of formaldehyde and isothiazole: Condensation reaction of formaldehyde and isothiazole under alkaline conditions to generate 1,2-thiazol-5-ylmethanol.
When using 1,2-thiazol-5-ylmethanol, you need to pay attention to safety issues:
1. 1,2-thiazol-5-ylmethanol is a chemical and should comply with relevant safety procedures to avoid contact with skin, eyes and mucous membranes.
2. Wear appropriate personal protective equipment such as lab gloves, goggles and lab clothes during operation.
3. During storage and use, keep 1,2-thiazol-5-ylmethanol away from fire and oxidant to prevent fire and explosion.
4. When disposing of 1,2-thiazol-5-ylmethanol waste, it should be properly disposed of in accordance with local regulations to avoid pollution to the environment.
1. Appearance: 1,2-thiazol-5-ylmethanol is a yellow crystalline solid.
2. Solubility: It is well soluble in water and soluble in organic solvents such as alcohols and ethers.
3. Chemical properties: 1,2-thiazol-5-ylmethanol is a weak acid, can react with strong alkali to generate the corresponding salt.
The application of 1,2-thiazol-5-ylmethanol mainly includes the following aspects:
1. Peroxide stabilizer: It is widely used as a peroxide stabilizer in tire rubber to extend the life of rubber products during service.
2. Metal corrosion inhibitor: Because it can form a stable complex with the metal surface, it is used as a metal corrosion inhibitor to delay the corrosion rate of the metal.
3. Osteogenic drugs: 1,2-thiazol-5-ylmethanol has the effect of promoting bone growth and repair, so it is used in the field of orthopedics.
The preparation method of 1,2-thiazol-5-ylmethanol mainly includes:
1. Sulfation of isothiazole: by reacting isothiazole with sulfuric acid, the sulfate of 1,2-thiazol-5-ylmethanol is obtained, and then 1,2-thiazol-5-ylmethanol is obtained by reduction reaction.
2. Condensation reaction of formaldehyde and isothiazole: Condensation reaction of formaldehyde and isothiazole under alkaline conditions to generate 1,2-thiazol-5-ylmethanol.
When using 1,2-thiazol-5-ylmethanol, you need to pay attention to safety issues:
1. 1,2-thiazol-5-ylmethanol is a chemical and should comply with relevant safety procedures to avoid contact with skin, eyes and mucous membranes.
2. Wear appropriate personal protective equipment such as lab gloves, goggles and lab clothes during operation.
3. During storage and use, keep 1,2-thiazol-5-ylmethanol away from fire and oxidant to prevent fire and explosion.
4. When disposing of 1,2-thiazol-5-ylmethanol waste, it should be properly disposed of in accordance with local regulations to avoid pollution to the environment.
Last Update：2024-04-10 22:40:09
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Email: 3008007409@qq.com
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