5-(p-Tolyl)-1,3,4-thiadiazol-2-amine

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine - Names and Identifiers

Name	5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine
Synonyms	26907-54-0 T5NN DSJ CZ ER D1 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine 5-p-Tolyl-[1,3,4]thiadiazol-2-ylamine 2-Amino-5-(p-tolyl)-1,3,4-thiadiazole 1,3,4-Thiadiazol-2-amine, 5-(p-tolyl)- 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine 5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine 1,3,4-Thiadiazol-2-aMine, 5-(4-Methylphenyl)- 1,3,4-Thiadiazol-2-amine, 5-(4-methylphenyl)- 5-(4-Methylphenyl)-1,3,4-thiadiazole-2-ylamine 2-Amino-5-(p-tolyl)-1,3,4-thiadiazole, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine, 5-(p-Tolyl)-1,3,4-thiadiazol-2-amine 4-(5-Amino-1,3,4-thiadiazol-2-yl)toluene, 5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
CAS	26907-54-0
InChI	InChI=1/C9H9N3S/c1-6-2-4-7(5-3-6)8-11-12-9(10)13-8/h2-5H,1H3,(H2,10,12)

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine - Physico-chemical Properties

Molecular Formula	C9H9N3S
Molar Mass	191.25
Density	1.281±0.06 g/cm3(Predicted)
Melting Point	218-222°C
Boling Point	364.9±35.0 °C(Predicted)
Flash Point	174.5°C
Vapor Presure	1.63E-05mmHg at 25°C
pKa	3.11±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.65

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine - Introduction

5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine is an organic compound with the chemical formula C9H9N3S.

Nature:
5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine is a pale yellow crystalline solid. It has a relatively high melting and boiling point and is soluble in many common organic solvents, such as dimethyl sulfoxide and ethylene glycol. It is stable at room temperature, but may decompose under heating conditions.

Use:
5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine is a pharmaceutical intermediate used to synthesize a variety of pharmaceutical compounds. It has a variety of biological activities, such as antibacterial, antiviral and anti-tumor effects. In addition, it can also be used as a reagent and catalyst in organic synthesis.

Method:
5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine can be synthesized by a variety of synthetic methods. The common method is to use a benzylamine compound and sulfuric acid to react under alkaline conditions to generate an intermediate thiadiazole salt, and then obtain the target compound by reduction.

Safety Information:
The toxicity information of 5-(4-methylphenyl)-1,3,4-thiadiazol-2-amine is less reported. As an organic compound, appropriate laboratory safety measures should be taken. It may have an irritating effect on the eyes, skin and respiratory system, so contact should be prevented during operation. When handling, care should be taken to use personal protective equipment, including gloves and protective glasses. The compound should be properly managed and disposed of during storage and handling to ensure safety.

Last Update：2024-04-09 20:52:54