5-(trifluoromethyl)-2,3-dihydro-1H-indole
5-Trifluoromethylindoline
CAS: 162100-55-2
Molecular Formula: C9H8F3N
5-(trifluoromethyl)-2,3-dihydro-1H-indole - Names and Identifiers
5-(trifluoromethyl)-2,3-dihydro-1H-indole - Physico-chemical Properties
| Molecular Formula | C9H8F3N |
| Molar Mass | 187.16 |
| Density | 1.264g/cm3 |
| Boling Point | 215.8°C at 760 mmHg |
| Flash Point | 84.3°C |
| Vapor Presure | 0.145mmHg at 25°C |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.481 |
5-(trifluoromethyl)-2,3-dihydro-1H-indole - Introduction
5-Trifluoromethylindoline, also known as TFMI, is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 5-Trifluoromethylindoline is a colorless or light yellow solid.
-Solubility: It can be dissolved in some organic solvents, such as chloroform and dimethylformamide.
-Melting point: about 65-75 degrees Celsius.
-Stability: It is stable at room temperature and may decompose when heated.
Use:
-As a reagent in Organic Synthesis: TFMI can be used as a fluorination reagent and has the ability to fluorinate functional groups such as alcohols and acids. It is commonly used in the synthesis of fluorinated derivatives in organic compounds.
-As a catalyst: TFMI can be used as a catalyst to participate in organic reactions and promote specific chemical changes.
-Application in drug research: It plays an important role in the synthesis of intermediates in some drug synthesis.
Method:
The preparation method of TFMI can be obtained by reacting 3-chloro-5-(trifluoromethyl) indoline with sodium trifluoromethylfluoride or sodium fluoromethylfluoride.
Safety Information:
- TFMI is relatively stable under general conditions, but it may decompose and produce harmful gases when heated, so care should be taken to avoid excessive heating.
-Adequate ventilation is required during operation to prevent excessive vapor concentrations, and personal protective equipment such as protective gloves and goggles are worn.
-Waste disposal should comply with local regulations and follow standards for the disposal of organic compounds.
Please note that the specific safety practices and hazards of TFMI refer to the relevant substance safety data sheets (MSDS) and chemical-related regulations.
Nature:
-Appearance: 5-Trifluoromethylindoline is a colorless or light yellow solid.
-Solubility: It can be dissolved in some organic solvents, such as chloroform and dimethylformamide.
-Melting point: about 65-75 degrees Celsius.
-Stability: It is stable at room temperature and may decompose when heated.
Use:
-As a reagent in Organic Synthesis: TFMI can be used as a fluorination reagent and has the ability to fluorinate functional groups such as alcohols and acids. It is commonly used in the synthesis of fluorinated derivatives in organic compounds.
-As a catalyst: TFMI can be used as a catalyst to participate in organic reactions and promote specific chemical changes.
-Application in drug research: It plays an important role in the synthesis of intermediates in some drug synthesis.
Method:
The preparation method of TFMI can be obtained by reacting 3-chloro-5-(trifluoromethyl) indoline with sodium trifluoromethylfluoride or sodium fluoromethylfluoride.
Safety Information:
- TFMI is relatively stable under general conditions, but it may decompose and produce harmful gases when heated, so care should be taken to avoid excessive heating.
-Adequate ventilation is required during operation to prevent excessive vapor concentrations, and personal protective equipment such as protective gloves and goggles are worn.
-Waste disposal should comply with local regulations and follow standards for the disposal of organic compounds.
Please note that the specific safety practices and hazards of TFMI refer to the relevant substance safety data sheets (MSDS) and chemical-related regulations.
Last Update：2024-04-09 19:05:47
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CAS: 162100-55-2
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CAS: 162100-55-2
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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