5-AMINO-2-CHLOROPYRIDINE

Name	2-Chloro-5-aminopyridine
Synonyms	Lcx-108 TIMTEC-BB SBB004234 Timtec-Bb Sbb004234 Amino Chloropyridine AMINO CHLOROPYRIDINE 6-CHLOROPYRIDIN-3-AMINE 6-Chloro-3-Pyridinamine 6-Chloropyridin-3-Amine 2-CHLORO-5-AMINOPYRIDINE 5-Amino-2-Chloropyridine 5- Bromo-2-Methoxyphenol 2-Chloro-5-aminopyridine 3-AMINO-6-CHLOROPYRIDINE 3-Amino-6-Chloropyridine 5-AMINO-2-CHLOROPYRIDINE 3-PYRIDINAMINE, 6-CHLORO- 5-Amino-2-Chloro Pyridine 3-Pyridinamine, 6-Chloro- 6-Chloro-Pyridin-3-Ylamine 6-CHLORO-PYRIDIN-3-YLAMINE 3-Pyridinamine,6-Chloro-(9ci)
CAS	5350-93-6
EINECS	226-322-3
InChI	InChI=1/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
InChIKey	QAJYCQZQLVENRZ-UHFFFAOYSA-N

Molecular Formula	C5H5ClN2
Molar Mass	128.56
Density	1.2417 (rough estimate)
Melting Point	81-83°C(lit.)
Boling Point	205.39°C (rough estimate)
Flash Point	130.7°C
Vapor Presure	0.00182mmHg at 25°C
Appearance	Bright brown crystal
Color	White to Brown
BRN	108891
pKa	1.94±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Sensitive	Sensitive to light and air
Refractive Index	1.5110 (estimate)
MDL	MFCD00006243

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29333999
Hazard Class	IRRITANT

Introduction	2-chloro-5-aminopyridine is a brown solid, which can be obtained by reducing nitro.
Uses	2-chloro-5-aminopyridine is a pyridine derivative that can be used as a pharmaceutical intermediate.
preparation	2-chloro -5-nitropyridine (5.0g,31.5mmol) is dissolved in acetic acid (50ml), iron powder (8.8g, 157.6mmol) is added in batches at room temperature, the reaction temperature is automatically increased to 80°C, the iron powder is added, and the reaction is kept at 40-50°C at room temperature for 2 hours. filter by suction, the filter residue is washed three times with a small amount of acetic acid, the filtrate is concentrated, the residue is adjusted to pH = 8 with saturated sodium bicarbonate solution, dichloromethane (100ml × 5) is extracted, the combined organic phase is washed with saturated salt water, anhydrous sodium sulfate is dried, and the compound 2-chloro-5-aminopyridine (3.9g,96%) is filtered and concentrated to be brown solid.

Last Update：2024-04-09 20:48:19

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