5-Acetylamino-6-formylamino-3-methyluracil - Names and Identifiers
Name | 5-Acetylamino-6-formylamino-3-methyluracil
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Synonyms | AFM AFMU 5-Acetylamino-6-formylamino-3-methyluracil 5-ACETYLAMINO-6-FORMYLAMINO-3-METHYLURACIL 3-Methyl-5-(acetylamino)-6-(formylamino)uracil 5-acetylaMino-6-forMylaMino-3-Methyluracil (AFMU) 5-ACETYLAMINO-6-FORMYLAMINO-3-METHYLURACIL Solution, 100ppm N-(4-(Formylamino)-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)acetamide Acetamide, N-(4-(formylamino)-1,2,3,6-tetrahydro-1-methyl-2,6-dioxo-5-pyrimidinyl)-
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CAS | 85438-96-6
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5-Acetylamino-6-formylamino-3-methyluracil - Physico-chemical Properties
Molecular Formula | C8H10N4O4
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Molar Mass | 226.19 |
Melting Point | 227-229°C |
Solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) |
Appearance | Solid |
Color | White to Pale Yellow |
Storage Condition | -20°C Freezer |
5-Acetylamino-6-formylamino-3-methyluracil - Introduction
It is also called AFAMU. The following are relevant Properties, Uses, manufacturing and safety information:
Nature:
-Appearance: White crystalline solid.
-Solubility: AFAMU has low solubility in water, and its solubility increases under acidic and alkaline conditions.
-Chemical structure: AFAMU belongs to pyrimidine compounds with amino and formyl functional groups.
Use:
-Medical field: AFAMU is an important nucleic acid damage repair enzyme (APE) inhibitor, which can be used to treat diseases related to DNA damage.
-Biochemical research: AFAMU can be used as a biomarker and molecular probe for the study of DNA repair and DNA synthesis.
Method:
The preparation method of AFAMU is relatively complicated and usually requires a multi-step reaction. A common method of preparation is to subject 3-methyluracil to multiple reactions, including acylation and formylation, to give AFAMU.
Safety Information:
- AFAMU is currently used in medicine and research, and there is no clear toxicity report.
-When handling and using AFAMU, it is recommended to take appropriate chemical laboratory safety operations, including wearing gloves and protective glasses.
-Avoid inhalation of dust or contact with skin, avoid ingestion.
-In case of contact or misuse, seek medical attention immediately.
Last Update:2024-04-09 15:18:05