5-Acetylpyrimidine-2,4(1H,3H)-dione
5-Acetyluracil
CAS: 6214-65-9
Molecular Formula: C6H6N2O3
5-Acetylpyrimidine-2,4(1H,3H)-dione - Names and Identifiers
| Name | 5-Acetyluracil |
| Synonyms | 5-Acetyluracil 5-ACETYLURACIL Cytosine Impurity 2 5-ACETYL-1H-PYRIMIDINE-2,4-DIONE 5-acetylpyriMidine-2,4(1H,3H)-dione 5-ACETYL-2,4(1H,3H)-PYRIMIDINEDIONE 5-Acetylpyrimidine-2,4(1H,3H)-dione 2,4(1H,3H)-pyrimidinedione, 5-acetyl- 2,4(1H,3H)-PyriMidinedione, 5-acetyl- 5-acetyl-1,2,3,4-tetrahydropyriMidine-2,4-dione |
| CAS | 6214-65-9 |
| InChI | InChI=1/C6H6N2O3/c1-3(9)4-2-7-6(11)8-5(4)10/h2H,1H3,(H2,7,8,10,11) |
| InChIKey | YNYDWEIQSDFDLK-UHFFFAOYSA-N |
5-Acetylpyrimidine-2,4(1H,3H)-dione - Physico-chemical Properties
| Molecular Formula | C6H6N2O3 |
| Molar Mass | 154.12 |
| Density | 1.351±0.06 g/cm3(Predicted) |
| Melting Point | 278 °C (dec.) (lit.) |
| Boling Point | 265°C |
| Flash Point | 206.6°C |
| Vapor Presure | 1.4E-07mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to Light yellow |
| Maximum wavelength(λmax) | ['282nm(EtOH:HCl=1:1)(lit.)'] |
| pKa | 7.04±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.511 |
| MDL | MFCD00151968 |
5-Acetylpyrimidine-2,4(1H,3H)-dione - Risk and Safety
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
5-Acetylpyrimidine-2,4(1H,3H)-dione - Introduction
5-Acetyluracil is an organic compound with the chemical formula C7H8N2O3. The NH group on the uracil ring in its structure is replaced by an acetyl group. The following is a description of some of the properties, uses, preparation and safety information of 5-Acetyluracil:
Nature:
1. Appearance: White to off-white crystalline solid.
2. solubility: soluble in ethanol, chloroform and benzene, slightly soluble in water.
3. melting point: about 192-196 ℃.
Use:
1. Pharmaceutical field: 5-Acetyluracil has antiviral and antitumor activity, and is used as an intermediate of some antitumor drugs.
2. Chemical research: In organic synthesis, 5-Acetyluracil can be used as a raw material for amination reagents or acylation reagents.
Preparation Method:
The preparation method of 5-Acetyluracil can be achieved by the following steps:
1. Uracil reacts with acetic anhydride under alkaline conditions to generate 5-acetyluracil.
2. in the presence of acyluracil, adding an appropriate amount of lye to generate the target product 5-Acetyluracil.
3. The reaction mixture was extracted and crystallized to obtain the pure product.
Safety Information:
5-Acetyluracil is a chemical under general conditions, and the following safety precautions should be noted:
1. prevent inhalation of dust, avoid contact with skin and eyes.
2. Wear protective glasses, gloves and protective clothing during operation.
3. Avoid contact with strong oxidants and other substances to avoid dangerous reactions.
4. storage should be sealed and placed in a cool, dry place, away from fire and flammable materials.
Nature:
1. Appearance: White to off-white crystalline solid.
2. solubility: soluble in ethanol, chloroform and benzene, slightly soluble in water.
3. melting point: about 192-196 ℃.
Use:
1. Pharmaceutical field: 5-Acetyluracil has antiviral and antitumor activity, and is used as an intermediate of some antitumor drugs.
2. Chemical research: In organic synthesis, 5-Acetyluracil can be used as a raw material for amination reagents or acylation reagents.
Preparation Method:
The preparation method of 5-Acetyluracil can be achieved by the following steps:
1. Uracil reacts with acetic anhydride under alkaline conditions to generate 5-acetyluracil.
2. in the presence of acyluracil, adding an appropriate amount of lye to generate the target product 5-Acetyluracil.
3. The reaction mixture was extracted and crystallized to obtain the pure product.
Safety Information:
5-Acetyluracil is a chemical under general conditions, and the following safety precautions should be noted:
1. prevent inhalation of dust, avoid contact with skin and eyes.
2. Wear protective glasses, gloves and protective clothing during operation.
3. Avoid contact with strong oxidants and other substances to avoid dangerous reactions.
4. storage should be sealed and placed in a cool, dry place, away from fire and flammable materials.
Last Update：2024-04-09 02:00:47
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CAS: 6214-65-9
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CAS: 6214-65-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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