5-Amino-1-bromo-3-fluorobenzene
3-Bromo-5-fluoroaniline
CAS: 7087-65-2
Molecular Formula: C6H3BrFNO2
5-Amino-1-bromo-3-fluorobenzene - Names and Identifiers
| Name | 3-Bromo-5-fluoroaniline |
| Synonyms | 3-Bromo-5-fluoroaniline 5-AMINO-1-BROMO-3-FLUOROBENZENE 5-Amino-1-bromo-3-fluorobenzene 1-Bromo-3-fluoro-5-nitrobenzene 1-bromo-3-fluoro-5-nitrobenzene Benzene, 1-bromo-3-fluoro-5-nitro- |
| CAS | 7087-65-2 |
| EINECS | 820-947-0 |
| InChI | InChI=1/C6H3BrFNO2/c7-4-1-5(8)3-6(2-4)9(10)11/h1-3H |
5-Amino-1-bromo-3-fluorobenzene - Physico-chemical Properties
| Molecular Formula | C6H3BrFNO2 |
| Molar Mass | 220 |
| Density | 1.808±0.06 g/cm3(Predicted) |
| Boling Point | 247.2±20.0 °C(Predicted) |
| Flash Point | 103.316°C |
| Vapor Presure | 0.041mmHg at 25°C |
| Appearance | Liquid |
| Color | Yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.58 |
5-Amino-1-bromo-3-fluorobenzene - Risk and Safety
| UN IDs | UN2810 |
| Hazard Class | 6.1 |
5-Amino-1-bromo-3-fluorobenzene - Introduction
3-Bromo-5-fluoroaniline is an organic compound with the formula C6H5BrFN. The following is an introduction to its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless to light yellow solid
-melting point: 61-65 ℃
-Boiling point: 244 ℃
-Density: 1.76g/cm³
-Solubility: Soluble in organic solvents such as ethanol, chloroform and dimethylformamide
Use:
3-Bromo-5-fluoroaniline is an important intermediate compound commonly used in organic synthesis. It can be used to synthesize drugs, pesticides, dyes and other organic compounds.
Preparation Method:
3-Bromo-5-fluoroaniline is usually prepared by halogenation of aniline. Specific steps can refer to the following synthetic route:
1. Dissolve aniline in hydrochloric acid, add sulfoxide (SO2) and stir.
2. slowly drop bromine at low temperature. 3-Bromoaniline is obtained.
3. Dissolve 3-bromoaniline in sulfuric acid, add sulfoxide and stir.
4. Slowly add ammonium bifluoride (NH4HF2) dropwise at low temperature. 3-Bromo-5-fluoroaniline was obtained.
5. distillation purification to obtain the target product.
Safety Information:
- 3-Bromo-5-fluoroaniline may be toxic and irritating to humans, and contact with skin, eyes and respiratory tract should be avoided.
-Be careful to use personal protective equipment such as gloves, goggles and protective masks during operation.
-Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
-During storage and use, pay attention to prevent fire and avoid contact with flammable materials.
Please note that the detailed nature, use, preparation and safety information of chemical reagents should be handled in a professional laboratory environment and strictly follow relevant safety procedures.
Nature:
-Appearance: Colorless to light yellow solid
-melting point: 61-65 ℃
-Boiling point: 244 ℃
-Density: 1.76g/cm³
-Solubility: Soluble in organic solvents such as ethanol, chloroform and dimethylformamide
Use:
3-Bromo-5-fluoroaniline is an important intermediate compound commonly used in organic synthesis. It can be used to synthesize drugs, pesticides, dyes and other organic compounds.
Preparation Method:
3-Bromo-5-fluoroaniline is usually prepared by halogenation of aniline. Specific steps can refer to the following synthetic route:
1. Dissolve aniline in hydrochloric acid, add sulfoxide (SO2) and stir.
2. slowly drop bromine at low temperature. 3-Bromoaniline is obtained.
3. Dissolve 3-bromoaniline in sulfuric acid, add sulfoxide and stir.
4. Slowly add ammonium bifluoride (NH4HF2) dropwise at low temperature. 3-Bromo-5-fluoroaniline was obtained.
5. distillation purification to obtain the target product.
Safety Information:
- 3-Bromo-5-fluoroaniline may be toxic and irritating to humans, and contact with skin, eyes and respiratory tract should be avoided.
-Be careful to use personal protective equipment such as gloves, goggles and protective masks during operation.
-Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
-During storage and use, pay attention to prevent fire and avoid contact with flammable materials.
Please note that the detailed nature, use, preparation and safety information of chemical reagents should be handled in a professional laboratory environment and strictly follow relevant safety procedures.
Last Update：2024-04-09 15:17:59
