5-Amino-2-cyanoanisole

5-Amino-2-cyanoanisole - Names and Identifiers

Name	4-amino-2-methoxybenzonitrile
Synonyms	NSC 30614 5-Amino-2-cyanoanisole 4-Cyano-3-Methoxyaniline 4-amino-2-methoxybenzonitrile 4-Amino-2-Methoxy-Benzonitrile 4-AMINO-2-METHOXY-BENZONITRILE Benzonitrile,4-aMino-2-Methoxy-
CAS	7251-09-4
InChI	InChI=1/C8H8N2O/c1-11-8-4-7(10)3-2-6(8)5-9/h2-4H,10H2,1H3

5-Amino-2-cyanoanisole - Physico-chemical Properties

Molecular Formula	C8H8N2O
Molar Mass	148.16
Density	1.17±0.1 g/cm3(Predicted)
Melting Point	102℃
Boling Point	351.2±27.0 °C(Predicted)
Flash Point	166.2°C
Vapor Presure	4.18E-05mmHg at 25°C
pKa	1.30±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.569

5-Amino-2-cyanoanisole - Introduction

It is an organic compound with the chemical formula of C8H8N2O. The following is a description of the properties, uses, preparation and safety information of this compound:

Nature:
-Appearance: White crystalline powder
-melting point: 126-130 ℃
-Boiling point: 366.3 ℃
-Solubility: Soluble in organic solvents such as chloroform and dimethyl sulfoxide

Use:
-is an important organic synthesis intermediate
-It can be used to synthesize various organic compounds, such as drugs and dyes
-In the field of medicine, it can be used as one of the starting materials for the synthesis of amino acid drugs

Preparation Method:
The preparation method usually involves the following steps:
1.3-methoxy-4-nitrobenzonitrile (pyridine) is reacted with sodium nitrite to generate the corresponding aromatic amine.
2. The aromatic amine is reacted with triethyl pyrophosphate (triethyl phosphite) at high temperature.
3. Add a dehydrating agent, such as phosphorus trichloride (phosphorus trichloride), and continue to react to generate the pill.

Safety Information:
-or powder irritant, avoid inhalation and contact with skin or eyes.
-Wear appropriate protective equipment, such as gloves and goggles, during use and handling.
-When conducting the experiment, please make sure to conduct it in a well-ventilated place to avoid inhaling dust or gas.
-The substance is not listed as a carcinogen, but long-term or heavy exposure should still be avoided.
-It should be stored in a dry, cool, well-ventilated place, away from fire sources and flammable substances.
-In use or disposal, should comply with the appropriate safety procedures and regulations.

Last Update：2024-04-09 02:00:47