5-Amino-2-hydroxypyridine
5-Amino-2-pyridinol
CAS: 33630-94-3;59315-46-7
Molecular Formula: C5H6N2O
5-Amino-2-hydroxypyridine - Names and Identifiers
5-Amino-2-hydroxypyridine - Physico-chemical Properties
| Molecular Formula | C5H6N2O |
| Molar Mass | 110.11 |
| Density | 1.208 |
| Melting Point | ca 180℃ |
| Boling Point | 206.4°C (rough estimate) |
| Flash Point | 91.8°C |
| Vapor Presure | 0.187mmHg at 25°C |
| Appearance | White-like solid |
| pKa | 12.87±0.10(Predicted) |
| Storage Condition | Refrigerated. |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD03427652 |
5-Amino-2-hydroxypyridine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| HS Code | 29333999 |
5-Amino-2-hydroxypyridine - Introduction
5-Amino-2-pyridinol is an organic compound with the chemical formula C5H6N2O, also known as 5-AP, which has the following properties:
1. Appearance: 5-Amino-2-pyridinol is a white to light yellow crystalline solid;
2. Solubility: Soluble in water, alcohols and acid solvents;
3. melting point: about 223-225 ℃;
4. Stability: It is a relatively stable compound, but it is easy to oxidize under light.
5-Amino-2-pyridinol is commonly used as an important intermediate in organic synthesis and has the following main uses:
1. pesticide: can be used for synthetic fungicides, pesticides and other pesticides;
2. drugs: can be used for the synthesis of anti-cancer drugs, antiviral drugs and antibacterial drugs;
3. Dyes: can be used as synthetic raw materials for dyes and coatings.
There are different ways to prepare 5-Amino-2-pyridinol, one of the common methods is:
Pyridine is reacted with nitrous acid to generate pyridine-2-one-N-oxide, which is then oxidized and reduced by hydrogen to obtain 5-Amino-2-pyridinol.
Regarding safety information, 5-Amino-2-pyridinol may have irritating effects on the skin and eyes, and may have toxic effects on the environment. Therefore, in the use of the process, should follow the appropriate safety procedures, and ensure that reasonable protective measures, including wearing appropriate protective glasses and gloves. Any work involving this compound should be carried out in a well-ventilated area. In addition, it should be stored in a dry, cool and sealed container, avoiding contact with oxidizing agents. In case of accidental exposure or ingestion, seek medical attention immediately.
1. Appearance: 5-Amino-2-pyridinol is a white to light yellow crystalline solid;
2. Solubility: Soluble in water, alcohols and acid solvents;
3. melting point: about 223-225 ℃;
4. Stability: It is a relatively stable compound, but it is easy to oxidize under light.
5-Amino-2-pyridinol is commonly used as an important intermediate in organic synthesis and has the following main uses:
1. pesticide: can be used for synthetic fungicides, pesticides and other pesticides;
2. drugs: can be used for the synthesis of anti-cancer drugs, antiviral drugs and antibacterial drugs;
3. Dyes: can be used as synthetic raw materials for dyes and coatings.
There are different ways to prepare 5-Amino-2-pyridinol, one of the common methods is:
Pyridine is reacted with nitrous acid to generate pyridine-2-one-N-oxide, which is then oxidized and reduced by hydrogen to obtain 5-Amino-2-pyridinol.
Regarding safety information, 5-Amino-2-pyridinol may have irritating effects on the skin and eyes, and may have toxic effects on the environment. Therefore, in the use of the process, should follow the appropriate safety procedures, and ensure that reasonable protective measures, including wearing appropriate protective glasses and gloves. Any work involving this compound should be carried out in a well-ventilated area. In addition, it should be stored in a dry, cool and sealed container, avoiding contact with oxidizing agents. In case of accidental exposure or ingestion, seek medical attention immediately.
Last Update：2024-04-09 20:48:19
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