5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE - Names and Identifiers

Name	5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE
Synonyms	METHYL 5-BROMO-2-HYDROXYISONICOTINATE 5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE METHYL 5-BROMO-2-HYDROXY-4-PYRIDINECARBOXYLATE Methyl 5-broMo-2-hydroxypyridine-4-carboxylate Methyl 5-broMo-2-oxo-1,2-dihydropyridine-4-carboxylate 5-Bromo-1,2-dihydro-2-oxo-pyridin-4-carboxylic acid methyl ester Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone Methyl 5-bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-2-hydroxy-4-(methoxycarbonyl)pyridine
CAS	913836-17-6

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE - Physico-chemical Properties

Molecular Formula	C7H6BrNO3
Molar Mass	232.03
Density	1.737±0.06 g/cm3(Predicted)
Boling Point	325.3±42.0 °C(Predicted)
pKa	8.96±0.10(Predicted)
Storage Condition	Inert atmosphere,Room Temperature

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

5-BROMO-4-METHOXYCARBONYL-2(1H)-PYRIDINONE - Reference Information

application

methyl 5-bromo-2-hydroxyisonicotinate is a carboxylate derivative, mainly used as a pharmaceutical intermediate.

preparation

in a three-mouth flask equipped with a mechanical stirring device and a reflux condenser tube, 80mL of methanol and 5-bromo -2-hydroxy isonicotinic acid are filled, 1.0mL of concentrated sulfuric acid is slowly added dropwise at room temperature, and the reflux reaction is carried out for 30h (thin layer chromatography tracking). At the end of the reaction, concentrate to 30mL, pour into 60mL of water, extract twice with 20mL of ether, wash the ether layer once with 5% sodium carbonate solution, then wash to neutral, dry with anhydrous magnesium sulfate, and evaporate to remove ether to obtain methyl 5-bromo-2-hydroxyisonicotinate.

Last Update：2024-04-09 20:48:19