5-BroM-3-nitro-4-pyridinol

Name	3-Bromo-5-nitropyridin-4(1H)-one
Synonyms	5-Brom-3-nitro-4-pyridinol 5-BroM-3-nitro-4-pyridinol 3-broMo-5-nitro-4-pyridone 3-Bromo-5-nitropyridin-4-ol 3-Bromo-5-nitro-4-pyridinol 4-pyridinol, 3-bromo-5-nitro- 4-Pyridinol, 3-broMo-5-nitro- 3-Bromo-5-nitropyridin-4(1H)-one 4-Hydroxy-3-nitro-5-broMopyridine 3-Bromo-4-hydroxy-5-nitropyridine 3-Bromo-4-Hydroxy-5-Nitropyridine 4(1H)-Pyridinone, 3-bromo-5-nitro-
CAS	31872-65-8
InChI	InChI=1/C5H3BrN2O3/c6-3-1-7-2-4(5(3)9)8(10)11/h1-2H,(H,7,9)

Molecular Formula	C5H3BrN2O3
Molar Mass	218.99
Density	2.006±0.06 g/cm3(Predicted)
Boling Point	341.8±37.0 °C(Predicted)
Flash Point	130.2°C
Vapor Presure	0.00192mmHg at 25°C
pKa	-1.63±0.38(Predicted)
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.647
MDL	MFCD08692339

Introduction	3-bromo-4-hydroxy-5-nitropyridine can be used as an intermediate in pharmaceutical synthesis. It can be prepared by reacting 3-nitropyridine -4-alcohol with acetic acid and bromine, it can be used to prepare another intermediate 3-bromo-N-cyclopropyl-5-nitropyridine-4-amine.
preparation	bromine (113g,713mmol,5eq) is added dropwise to a solution of 3-nitropyridine -4-alcohol (20g,142.76mmol,1eq.) in 50% aqueous acetic acid (250mL), the resulting mixture was stirred at room temperature for 20 hours, the resulting precipitate was filtered and washed with water to obtain 25g of intermediate 3-bromo-4-hydroxy-5-nitropyridine.

Last Update：2024-04-09 20:49:11