5-Bromo-1-tert-butoxycarbonylindole
TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE
CAS: 182344-70-3
Molecular Formula: C13H14BrNO2
5-Bromo-1-tert-butoxycarbonylindole - Names and Identifiers
| Name | TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE |
| Synonyms | N-Boc-5-bromoindole 1-BOC-5-bromoindole 5-Bromo-1-tert-butoxycarbonylindole 5-Bromo-1-(t-Butoxycarbonyl)-1H-indole TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE 5-BROMO-1-(TERT-BUTOXYCARBONYL)-1H-INDOLE TERT-BUTYL 5-BROMO-1H-INDOLE-1-CARBOXYLATE 5-bromo-1-indolecarboxylic acid tert-butyl ester |
| CAS | 182344-70-3 |
| InChI | InChI=1/C13H14BrNO2/c1-13(2,3)17-12(16)15-7-6-9-8-10(14)4-5-11(9)15/h4-8H,1-3H3 |
5-Bromo-1-tert-butoxycarbonylindole - Physico-chemical Properties
| Molecular Formula | C13H14BrNO2 |
| Molar Mass | 296.16 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Melting Point | 56-57°C(lit.) |
| Boling Point | 367.9±34.0 °C(Predicted) |
| Flash Point | 176.3°C |
| Vapor Presure | 1.33E-05mmHg at 25°C |
| Appearance | Solid |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.576 |
| Physical and Chemical Properties | WGK Germany:3 |
5-Bromo-1-tert-butoxycarbonylindole - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
5-Bromo-1-tert-butoxycarbonylindole - Introduction
TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE is an organic compound that has the following properties:
1. Appearance: White crystalline solid.
2. Molecular formula: C13H14BrNO2.
3. Molecular weight: 297.17g/mol.
4. Melting point: About 180-182 degrees Celsius.
The main use of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE is as an intermediate in organic synthesis. It can be used to synthesize indole compounds, which are commonly used in drug synthesis, natural product synthesis and other fields. The Boc protecting group of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE can play a protective role during the synthesis to protect the active nucleophilic site from interference.
The preparation method of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE generally includes the following steps:
1.5-bromoindole reacts with 1-hydroxymethyl cyclopropylamine to generate the corresponding nucleophile.
2. Reacting a nucleophile with a N-Boc protecting reagent to obtain the TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE.
When using the TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE, you need to pay attention to its safety information:
1. This compound may have certain toxicity to human body, should avoid direct contact with skin and inhalation of its dust.
2. During operation, it is recommended to wear appropriate protective gloves and glasses to ensure good ventilation.
3. Storage should be sealed, away from the fire and oxidant.
Please note that TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE is a chemical reagent for laboratory use only and requires professional operation. Please read the relevant safety data sheets and operating instructions carefully before use.
1. Appearance: White crystalline solid.
2. Molecular formula: C13H14BrNO2.
3. Molecular weight: 297.17g/mol.
4. Melting point: About 180-182 degrees Celsius.
The main use of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE is as an intermediate in organic synthesis. It can be used to synthesize indole compounds, which are commonly used in drug synthesis, natural product synthesis and other fields. The Boc protecting group of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE can play a protective role during the synthesis to protect the active nucleophilic site from interference.
The preparation method of TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE generally includes the following steps:
1.5-bromoindole reacts with 1-hydroxymethyl cyclopropylamine to generate the corresponding nucleophile.
2. Reacting a nucleophile with a N-Boc protecting reagent to obtain the TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE.
When using the TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE, you need to pay attention to its safety information:
1. This compound may have certain toxicity to human body, should avoid direct contact with skin and inhalation of its dust.
2. During operation, it is recommended to wear appropriate protective gloves and glasses to ensure good ventilation.
3. Storage should be sealed, away from the fire and oxidant.
Please note that TERT-BUTYL 5-BROMOINDOLE-1-CARBOXYLATE is a chemical reagent for laboratory use only and requires professional operation. Please read the relevant safety data sheets and operating instructions carefully before use.
Last Update：2024-04-09 19:05:47
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Product Name: Tert-Butyl 5-Bromoindole-1-Carboxylate Visit Supplier Webpage Request for quotationCAS: 182344-70-3
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Mobile: 18021002903
QQ: 3008007409
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