5-Bromo-2-Methoxy-6-Methylpyridine
5-Bromo-2-methoxy-6-picoline
CAS: 126717-59-7
Molecular Formula: C7H8BrNO
5-Bromo-2-Methoxy-6-Methylpyridine - Names and Identifiers
5-Bromo-2-Methoxy-6-Methylpyridine - Physico-chemical Properties
| Molecular Formula | C7H8BrNO |
| Molar Mass | 202.05 |
| Density | 1.468g/mLat 25℃ |
| Boling Point | 86°C/10mmHg(lit.) |
| Flash Point | 106°C |
| Vapor Presure | 0.25mmHg at 25°C |
| Appearance | Liquid |
| Color | Colorless |
| pKa | 1.76±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.548 |
5-Bromo-2-Methoxy-6-Methylpyridine - Risk and Safety
| Risk Codes | R41 - Risk of serious damage to eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
5-Bromo-2-Methoxy-6-Methylpyridine - Introduction
2-methoxy -5-bromo -6-methyl pyridine is an organic compound, chemical structure is C9H10BrNO.
Nature:
-Appearance: Colorless solid at room temperature.
-Solubility: Soluble in common organic solvents, such as ethanol, dimethylformamide, acetone, etc.
-Melting point: approximately 30-33°C.
-Boiling point: approximately 274°C.
-Density: about 1.45g/cm³.
Use:
-2-methoxy-5-bromo-6-methylpyridine can be used as an important intermediate in organic synthesis for the preparation of other compounds or pharmaceuticals.
-The compound can also be used as a raw material for pesticides and herbicides.
Method:
The preparation of 2-methoxy-5-bromo-6-methylpyridine can be carried out by the following steps:
1. Esterification of methoxyacetophenone and bromopropane in the presence of sodium hydroxide to obtain an ester of 2-methoxy-5-bromo-6-methylpyridine.
2. The ester is converted to 2-methoxy-5-bromo-6-methylpyridine by ester hydrolysis.
Safety Information:
2-Methoxy-5-bromo-6-methylpyridine is less dangerous under correct operation. However, in the case of any chemical, the following precautions should be taken:
-Avoid contact with skin, eyes and mucous membranes.
-Wear protective gloves and goggles during use.
-Avoid inhaling dust or gas.
-Store in a dry, well-ventilated place.
-Avoid contact with oxidants and strong acids.
Please note that this information is for reference only. Please read the relevant safety information carefully before using the compound and take appropriate protective measures according to the actual situation.
Nature:
-Appearance: Colorless solid at room temperature.
-Solubility: Soluble in common organic solvents, such as ethanol, dimethylformamide, acetone, etc.
-Melting point: approximately 30-33°C.
-Boiling point: approximately 274°C.
-Density: about 1.45g/cm³.
Use:
-2-methoxy-5-bromo-6-methylpyridine can be used as an important intermediate in organic synthesis for the preparation of other compounds or pharmaceuticals.
-The compound can also be used as a raw material for pesticides and herbicides.
Method:
The preparation of 2-methoxy-5-bromo-6-methylpyridine can be carried out by the following steps:
1. Esterification of methoxyacetophenone and bromopropane in the presence of sodium hydroxide to obtain an ester of 2-methoxy-5-bromo-6-methylpyridine.
2. The ester is converted to 2-methoxy-5-bromo-6-methylpyridine by ester hydrolysis.
Safety Information:
2-Methoxy-5-bromo-6-methylpyridine is less dangerous under correct operation. However, in the case of any chemical, the following precautions should be taken:
-Avoid contact with skin, eyes and mucous membranes.
-Wear protective gloves and goggles during use.
-Avoid inhaling dust or gas.
-Store in a dry, well-ventilated place.
-Avoid contact with oxidants and strong acids.
Please note that this information is for reference only. Please read the relevant safety information carefully before using the compound and take appropriate protective measures according to the actual situation.
Last Update：2024-04-09 20:45:29
