5-Bromo-2-chloropyrimidin-4-amine

5-Bromo-2-chloropyrimidin-4-amine - Names and Identifiers

Name	4-Amino-5-bromo-2-chloropyrimidine
Synonyms	5-BroMo-2-chloro-4-pyriMidinaMine 4-Amino-5-bromo-2-chloropyrimidin 5-Bromo-2-chloropyrimidin-4-amine 4-AMINO-5-BROMO-2-CHLOROPYRIMIDINE 4-Amino-5-bromo-2-chloropyrimidine 4-Pyrimidinamine, 5-bromo-2-chloro- 5-BroMo-2-chloro-pyriMidin-4-ylaMine 5-Bromo-2-chloropyrimidin-4-amine, 4-Amino-5-bromo-2-chloro-1,3-diazine
CAS	205672-25-9
InChI	InChI=1/C4H3BrClN3/c5-2-1-8-4(6)9-3(2)7/h1H,(H2,7,8,9)

5-Bromo-2-chloropyrimidin-4-amine - Physico-chemical Properties

Molecular Formula	C4H3BrClN3
Molar Mass	208.44
Density	1.960±0.06 g/cm3(Predicted)
Melting Point	187-188 °C(Solv: acetonitrile (75-05-8))
Boling Point	369.8±22.0 °C(Predicted)
Flash Point	177.5°C
Water Solubility	Slightly soluble in water.
Vapor Presure	1.16E-05mmHg at 25°C
Appearance	Liquid
Color	Clear brown to purple
pKa	0.68±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.66
MDL	MFCD07782040

5-Bromo-2-chloropyrimidin-4-amine - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	UN2811
HS Code	29335990

5-Bromo-2-chloropyrimidin-4-amine - Introduction

Lin (also known as 5-bromo-4-chloro-2-aminopyrimidine) is an organic compound with the chemical formula C5H4BrClN2. The following is an introduction to its nature, use, preparation and safety information:

Nature:
1.4-Amino-5-bromo-2-chloropyrimidine is a solid, often in the form of white crystals.
2. Its melting point is about 290-293 degrees Celsius, insoluble in water, slightly soluble in ethanol and dimethyl sulfoxide.

Use:
1.4-Amino-5-bromo-2-chloropyrimidine is an intermediate compound, widely used in pesticides, dyes and pharmaceuticals.
2. It can be used as an important intermediate in the synthesis of pesticides, pesticides, fungicides and herbicides and other agricultural chemicals.
3. In addition, it is also used in dye synthesis and organic synthesis in the field of medicine.

Method:
It can be synthesized by the following steps:
1. First, 2,4,5-tribromopyrimidine reacts with cuprous chloride (D-CuCl) to generate 5-bromo -2-chloropyrimidine.
2. Then, 5-bromo-2-chloropyrimidine is reacted with ammonia to generate pyridine.

Safety Information:
1.4-Amino-5-bromo-2-chloropyrimidine should be stored and used as hazardous chemicals, need to pay attention to safety protection.
2. Avoid skin contact and inhalation, use should wear protective gloves and masks and other personal protective equipment.
3. If it comes into contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
4. During storage and disposal, chemical safety practices should be met to prevent accidents.

Last Update：2024-04-09 21:01:54