5-Bromo-2-methyl-1,3-diazine

5-Bromo-2-methyl-1,3-diazine - Names and Identifiers

Name	5-Bromo-2-methylpyrimidine
Synonyms	5-Bromo-2-methylpyrimidine 5-Bromo-2-methyl-Pyrimidine 5-BROMO-2-METHYL-PYRIMIDINE 5-bromo-2-methyl-pyrimidi... 5-Bromo-2-methyl-1,3-diazine PyriMidine, 5-broMo-2-Methyl- 2-methyl-5-bromo-1,3-pyrimidine
CAS	7752-78-5
EINECS	691-361-9
InChI	InChI=1/C5H5BrN2/c1-4-7-2-5(6)3-8-4/h2-3H,1H3

5-Bromo-2-methyl-1,3-diazine - Physico-chemical Properties

Molecular Formula	C5H5BrN2
Molar Mass	173.01
Density	1.596±0.06 g/cm3(Predicted)
Melting Point	80.0 to 85.0 °C
Boling Point	195.2±13.0 °C(Predicted)
Flash Point	71.885°C
Solubility	soluble in Methanol
Vapor Presure	0.593mmHg at 25°C
Appearance	Solid
Color	Light yellow to Brown
Maximum wavelength(λmax)	['266nm(EtOH)(lit.)']
pKa	0.46±0.22(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.558

5-Bromo-2-methyl-1,3-diazine - Risk and Safety

Hazard Symbols

Xi - Irritant

5-Bromo-2-methyl-1,3-diazine - Reference Information

Application

2-methyl-5-bromopyrimidine is a common organic Synthon, it can be used as a molecular backbone to participate in the synthetic modification of bioactive molecules.

prepare

a dry 10-liter 4-neck round-bottom flask was blown with nitrogen and allowed to maintain an inert atmosphere of nitrogen, A solution of 5-bromo-2-iodopyrimidine (590g, 2.07 mol) was dissolved in tetrahydrofuran (3 L). 1
M dimethylzinc solution (3.1 1 L,3.11 mol) was slowly added dropwise with stirring at 0 °c, and then Pd
(PPh3) was added to the reaction system. 4(120g, 104 mmol). The resulting solution was stirred at 0°C for 3 hours, quenched by addition of 600 aqueous NH4Cl, and the resulting solution was extracted with 2 x 1.5 L
EtOAc. The organic extracts were combined, dried over anhydrous magnesium sulfate and concentrated by spin-drying under vacuum. The product is obtained by purification of the residue by chromatography on SiO2 (1:50
EtOAc/petroleum ether).

Last Update：2024-04-09 15:16:52