5-Bromo-3-chloropyridin-2-ol

5-Bromo-3-chloropyridin-2-ol - Names and Identifiers

Name	5-Bromo-3-chloro-2-pyridinone
Synonyms	5-Bromo-3-chloropyridin-2-ol 5-BROMO-3-CHLOROPYRIDIN-2-OL 5-Bromo-3-chloro-2-pyridinone 2-pyridinol, 5-bromo-3-chloro- 5-bromo-3-chloro-3H-pyridin-2-one 5-Bromo-3-chloro-2(1H)-pyridinone 5-Bromo-3-chloropyridin-2(1H)-one 5-Bromo-3-chloro-2-hydroxypyridine 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE 2-Hydroxy-3-chloro-5-bromopyridine 2(1H)-Pyridinone, 5-bromo-3-chloro-
CAS	58236-70-7
InChI	InChI=1/C5H3BrClNO/c6-3-1-4(7)5(9)8-2-3/h1-2,4H

5-Bromo-3-chloropyridin-2-ol - Physico-chemical Properties

Molecular Formula	C5H3BrClNO
Molar Mass	208.44
Density	1.91±0.1 g/cm3(Predicted)
Melting Point	199-202℃
Boling Point	275.4±40.0 °C(Predicted)
Flash Point	130°C
Vapor Presure	0.00196mmHg at 25°C
Appearance	Solid
pKa	8.48±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.642

5-Bromo-3-chloropyridin-2-ol - Introduction

It is an organic compound with the chemical formula of C5H3BrClNO. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to light yellow crystal or powder.
-Melting point: Its melting point is in the range of about 125-127 ℃.
-Solubility: Low solubility in water, soluble in organic solvents such as alcohols, chlorinated hydrocarbons and ketones.

Use:
-is often used in organic synthesis reaction as an important intermediate.
-It can be used to synthesize biologically active compounds, pharmaceutical intermediates, pesticides and other organic chemicals.
-For example, it can be used to prepare anti-cancer drugs, pesticides and other drugs.

Preparation Method:
The preparation method can be achieved by the following steps:
1. First, pyridine is reacted with ozone as an oxidant under appropriate reaction conditions to form 5-oxopyridine.
2. then, 5-oxopyridine and appropriate amount of hydrobromic acid and chlorinated alkyl reaction, bromination and chlorination reaction.

Safety Information:
-It needs to be handled with care because it may be toxic to the human body.
-Appropriate protective measures should be taken during use or handling, such as wearing protective gloves, glasses and masks.
-When used in a laboratory environment, it is necessary to ensure good ventilation and avoid inhalation or contact with skin.
-Work involving this compound is best carried out under the guidance of experienced people and follow relevant safety procedures.

Last Update：2024-04-09 21:32:42