5-Bromoindoline
5-Bromoindoline
CAS: 22190-33-6
Molecular Formula: C8H8BrN
5-Bromoindoline - Names and Identifiers
| Name | 5-Bromoindoline |
| Synonyms | AKOS BC-0891 5-BROMOINDOLINE 5-Bromoindoline 5-bromodihydroindole 5-BroMo-2,3-dihydroindole 5-BROMO-2,3-DIHYDRO-1H-INDOLE 5-Bromo-2,3-dihydro-1H-indole 1H-Indole, 5-broMo-2,3-dihydro- |
| CAS | 22190-33-6 |
| EINECS | 629-063-8 |
| InChI | InChI=1/C8H8BrN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2 |
5-Bromoindoline - Physico-chemical Properties
| Molecular Formula | C8H8BrN |
| Molar Mass | 198.06 |
| Density | 1.5240 g/cm3 |
| Melting Point | 36-40 °C (lit.) |
| Boling Point | 114-115°C 5mm |
| Flash Point | >230°F |
| Solubility | DMSO, Methanol |
| Vapor Presure | 0.00334mmHg at 25°C |
| Appearance | Brown low melting point solid |
| Color | Off-White |
| BRN | 121590 |
| pKa | 4.35±0.20(Predicted) |
| Storage Condition | -20°C |
| Sensitive | `sensitive` to air and heat |
| Refractive Index | 1.63 |
| MDL | MFCD00027410 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
5-Bromoindoline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29339900 |
| Packing Group | III |
5-Bromoindoline - Reference Information
| Uses | 5-bromodihydroindole is an indole derivative, indole compounds are widely present in nature, and many benzene rings contain substituents Indole has physiological activity. It can be used as an organic intermediate and has important applications in the synthesis of medicines and dyes. |
| synthesis method | 30 moles of N-formylindoline compound 3 are dissolved in 50ml of dichloromethane, then 15 moles of dibromohydantoin are added to it, and the reaction is carried out at -10~0 degrees until the raw materials disappear. after washing, washing, concentration and crystallization of sodium bisulfite aqueous solution, compound 4 is obtained with 85% yield and 95% product purity. then dissolve 20 moles of 5-bromo-N-formyl indoline in 40ml of methanol, add 25 moles of potassium hydroxide aqueous solution to it, heat to 60-65 degrees to react until the raw material disappears, then add water to quench, concentrate, extract dichloromethane, concentrate and crystallize, and dry to obtain compound 5, I .e. 5-bromodihydroindole; The yield is 80% and the purity of the product is 93%. |
Last Update：2024-04-09 02:00:07
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