5-Bromothiophene-2-carbaldehyde

5-Bromothiophene-2-carbaldehyde - Names and Identifiers

Name	5-Bromo-2-thiophenecarboxaldehyde
Synonyms	LABOTEST-BB LT00112291 5-Bromo-2-thienylaldehyde 5-BROMO-2-FORMYLTHIOPHENE 5-Bromo-2-formylthiophene 5-Bromothiophene-2-aldehyde 5-BROMOTHIOPHENE-2-ALDEHYDE 5-BROMO-2-THIOPHENECARBALDEHYDE 5-Bromothiophene-2-carbaldehyde 5-Bromo-2-thiophenecarbaldehyde 5-BROMO-THIOPHENE-2-CARBALDEHYDE 5-Bromo-thiophene-2-carbaldehyde 5-BROMOTHIOPHENE-2-CARBOXALDEHYDE 2-Bromo-5-thiophenecarboxaldehyde 5-Bromothiophene-2-carboxaldehyde 5-BROMO-2-THIOPHENECARBOXALDEHYDE 5-Bromo-2-thiophenecarboxaldehyde 2-Thiophenecarboxaldehyde, 5-bromo-
CAS	4701-17-1
EINECS	225-176-8
InChI	InChI=1/C5H3BrOS/c6-5-2-1-4(3-7)8-5/h1-3H
InChIKey	GFBVUFQNHLUCPX-UHFFFAOYSA-N

5-Bromothiophene-2-carbaldehyde - Physico-chemical Properties

Molecular Formula	C5H3BrOS
Molar Mass	191.05
Density	1.607g/mLat 25°C(lit.)
Melting Point	55°C
Boling Point	105-107°C11mm Hg(lit.)
Flash Point	210°F
Solubility	Soluble in chloroform and methanol.
Vapor Presure	0.065mmHg at 25°C
Appearance	Liquid
Color	Clear yellow to brown
BRN	108404
Storage Condition	2-8°C
Sensitive	Air Sensitive
Refractive Index	n20/D 1.637(lit.)
MDL	MFCD00005432
Physical and Chemical Properties	Boiling point 105-107 ° C 11mm Hg(lit.) density 1.607g/mL at 25°C(lit.) refractive index n20/D 1.637(lit.) flash point 210 °F storage conditions 0-6°C Sensitive Air BRN 108404
Use	Usually used to prepare 5-[18F]fluoro-2-2-thiophene carboxaldehyde.

5-Bromothiophene-2-carbaldehyde - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S22 - Do not breathe dust. S36 - Wear suitable protective clothing.
WGK Germany	3
TSCA	N
HS Code	29349990
Hazard Note	Irritant/Air Sensitive

5-Bromothiophene-2-carbaldehyde - Reference Information

NIST chemical information

Information provided by: webbook.nist.gov (external link)

production method

95.5g(0.33mol) of tribromide oxyphosphate was added to a reaction bottle containing 45g(0.32mol)N-methylformaniline and 32.6g(0.2mol) 2-bromothiophene (carried out in a fume hood). At this time, a violent reaction occurs and cooling to reduce the rate of hydrogen bromide production. Then put it on a steam bath and heat it for 1h. After cooling, it is neutralized in an aqueous solution of sodium acetate. Steam distillation, the distillate is extracted with ether, the ether extract is washed with 6mol/L hydrochloric acid and 5% sodium bicarbonate, and then dried with anhydrous sodium sulfate. Distilled to obtain 20.5 g5-bromo-2-thiophene formaldehyde with a boiling point of 80~83 ℃(267Pa).

Last Update：2024-04-09 21:04:16