5-Bromouridine
5-Bromouridine
CAS: 957-75-5
Molecular Formula: C9H11BrN2O6
5-Bromouridine - Names and Identifiers
| Name | 5-Bromouridine |
| Synonyms | NSC 38296 BRN 0033664 5-Bromouridine 5-bromo-uridin Uridine, 5-bromo- 5-Bromo-D-uridine 5-BROMO-URIDINE(5-BRU) 5-Bromouracil ribonucleoside 5-bromouracil-1-β-d-ribofuranoside 1-beta-Ribofuranosyl-5-bromo-uracil 1-beta-ribofuranosyl-5-bromo-uracil 5-24-06-00337 (Beilstein Handbook Reference) 5-bromo-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione |
| CAS | 957-75-5 |
| EINECS | 213-486-6 |
| InChI | InChI=1/C9H11BrN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17) |
5-Bromouridine - Physico-chemical Properties
| Molecular Formula | C9H11BrN2O6 |
| Molar Mass | 323.1 |
| Density | 1.9322 (rough estimate) |
| Melting Point | 180-182 °C (dec.) (lit.) |
| Specific Rotation(α) | -11 º (c=2 in H2O) |
| Water Solubility | Insoluble in water. |
| Solubility | Water (Sonicated) |
| Appearance | Solid |
| Color | Off-White |
| BRN | 33664 |
| pKa | 7.73±0.10(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.6520 (estimate) |
| MDL | MFCD00006528 |
5-Bromouridine - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | YU7300000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29349990 |
5-Bromouridine - Introduction
5-Bromouridine(5-Bromouridine) is a uridine derivative containing bromine. Its chemical formula is C9H11BrN2O6.
In terms of properties, 5-Bromouridine is a white crystalline solid that is readily soluble in water. Its solubility is related to temperature, and with the increase of temperature, the solubility will also increase.
5-Bromouridine has a wide range of applications in vivo. One of its main uses is as a marker for DNA and RNA. By introducing 5-Bromouridine into a strand of DNA or RNA, the molecule can be labeled with a radioisotope or pigment, allowing it to be traced and studied. In addition, 5-Bromouridine can also be used as an intermediate of antiviral and antitumor drugs.
5-Bromouridine can be prepared by reacting uridine with bromoacetyl under alkaline conditions. Specific preparation methods can be found in the literature of organic synthesis.
Regarding safety information, 5-Bromouridine is generally relatively safe under normal conditions of use. However, as a chemical, it is still necessary to follow laboratory safety procedures. If necessary, wear protective gloves and safety glasses to avoid direct contact with skin and eyes. At the same time, it should be used in a well-ventilated place and away from fire and flammable materials. When handling and disposing of waste, it should be disposed of in accordance with local regulations. Always read and follow the safety data sheets (MSDS) of the relevant chemicals before use.
In terms of properties, 5-Bromouridine is a white crystalline solid that is readily soluble in water. Its solubility is related to temperature, and with the increase of temperature, the solubility will also increase.
5-Bromouridine has a wide range of applications in vivo. One of its main uses is as a marker for DNA and RNA. By introducing 5-Bromouridine into a strand of DNA or RNA, the molecule can be labeled with a radioisotope or pigment, allowing it to be traced and studied. In addition, 5-Bromouridine can also be used as an intermediate of antiviral and antitumor drugs.
5-Bromouridine can be prepared by reacting uridine with bromoacetyl under alkaline conditions. Specific preparation methods can be found in the literature of organic synthesis.
Regarding safety information, 5-Bromouridine is generally relatively safe under normal conditions of use. However, as a chemical, it is still necessary to follow laboratory safety procedures. If necessary, wear protective gloves and safety glasses to avoid direct contact with skin and eyes. At the same time, it should be used in a well-ventilated place and away from fire and flammable materials. When handling and disposing of waste, it should be disposed of in accordance with local regulations. Always read and follow the safety data sheets (MSDS) of the relevant chemicals before use.
Last Update：2024-04-10 22:30:50
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Multiple Specifications
Product Name: 5-Bromouridine Request for quotationCAS: 957-75-5
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Email: Lucy@verypharm.com
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