5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE

5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE - Names and Identifiers

Name	5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE
Synonyms	Sertindole Impurity 2 5-Chloro-1-(4-fluorophenyl)-3-(4-piperidinyl)-1H-indole 5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE 1H-Indole, 5-chloro-1-(4-fluorophenyl)-3-(4-piperidinyl)-
CAS	138900-27-3

5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE - Physico-chemical Properties

Molecular Formula	C19H18ClFN2
Molar Mass	328.82
Density	1.30
Boling Point	473℃
Flash Point	240℃
Storage Condition	2-8°C(protect from light)

5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE - Upstream Downstream Industry

Downstream Products

SERTINDOLE

5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE - Introduction

5-chroo-1-(4-FLUORO-PHENYL)-is an organic compound with the chemical formula C21H16ClFN2, which has an indole structure and substituents of benzene ring and piperidine ring. The following is its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless or yellowish solid
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane
-Melting point: About 80-85 ℃
-Molecular weight: 368.82g/mol

Use:
-Drug research: 5-CHLORO-1-(4-FLUORO-PHENYL)-is an important organic synthesis intermediate, commonly used in the synthesis of new drugs, compound exploration and drug research.

Method:
5-choro-1-(4-FLUORO-PHENYL)-is prepared in a variety of ways, and the following is a brief introduction to a common method:
1. 4-piperidinyl benzoic acid was synthesized by reacting 4-fluorobenzoic acid with 4-piperidinyl amine.
2. Use anhydrous acetic acid to rearrange 4-piperidinyl benzoic acid to generate N-benzoyl -4-piperidinamine.
3. Reacting n-benzoyl-4-piperidinamine with indole to give 5-benzoyl-3-(4-piperidinyl)-1H-indole.
4. Finally, the product reacts with chlorine to obtain the target product 5-CHLORO-1-(4-FLUORO-PHENYL)-phenyl.

Safety Information:
-The safety data of this compound is limited, so it must be handled with caution.
-Wear protective glasses and gloves during operation.
-Avoid inhalation or contact with skin to avoid harm to health.
-Avoid direct sunlight during storage, keep it sealed, and keep it away from fire and heat sources.

Last Update：2024-04-09 21:00:56