5-CHLORO-3-NITRO-2-PYRIDINOL

5-CHLORO-3-NITRO-2-PYRIDINOL - Names and Identifiers

Name	5-chloro-3-nitropyridin-2-ol
Synonyms	5-CHLORO-3-NITRO-2-PYRIDINOL 5-chloro-3-nitropyridin-2-ol 5-CHLORO-3-NITROPYRIDIN-2-OL 5-chloro-3-nitropyridin-2(1H)-one 2-hydroxy-3-nitro-5-chloropyridine 5-CHLORO-2-HYDROXY-3-NITROPYRIDINE 5-Chloro-2-hydroxy-3-nitropyridine 2-Hydroxy-5-chloro-3-nitropyridine
CAS	21427-61-2
EINECS	622-609-6
InChI	InChI=1/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

5-CHLORO-3-NITRO-2-PYRIDINOL - Physico-chemical Properties

Molecular Formula	C5H3ClN2O3
Molar Mass	174.54
Density	1.61±0.1 g/cm3(Predicted)
Melting Point	232-236 °C
Boling Point	284.1±40.0 °C(Predicted)
Flash Point	125.6°C
Vapor Presure	0.00303mmHg at 25°C
Appearance	Solid
BRN	383852
pKa	6.31±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.602
MDL	MFCD00114884

5-CHLORO-3-NITRO-2-PYRIDINOL - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. S36 - Wear suitable protective clothing. S37 - Wear suitable gloves.
WGK Germany	3
HS Code	29337900
Hazard Class	IRRITANT

5-CHLORO-3-NITRO-2-PYRIDINOL - Reference Information

use

substituted nitropyridine synthesis began in the 2090 s. research found that this kind of energetic compound has good stability and strong explosiveness, and can be used in military and civil explosive products, explosive charge, explosive charge and energetic catalyst of blasting equipment.

preparation

5-chloro-2-hydroxy-3-nitropyridine was prepared by nitro-talk and diazotization hydrolysis with 2, 6-dichloropyridine as the starting material. The synthesis reaction formula is as follows: fig. 1 5-chloro -2-hydroxy -3-nitropyridine synthesis reaction formula at room temperature, 80 mL concentrated sulfuric acid is added into 150 mL three-mouth flask, 7.4g (0.05 mol) 2,6-dichloropyridine is slowly added under the condition of magnetic stirring, 10.1g (0.1 mol) potassium nitrate is slowly added after it is completely dissolved, and stirring is continued for 30 min after adding, slowly raise the temperature to 120 ℃, keep the temperature for 10 h. After the reaction is completed, cool the reaction mixture to room temperature, slowly pour it into crushed ice, immediately precipitate a large amount of white solid, wash with cold water, filter by suction, and dry to obtain 7.75g of white solid 2, 6-dichloro-3-nitropyridine with 80.2% yield. 2, 6-dichloro-3-nitropyridine is dissolved or dispersed in dilute hydrochloric acid solution, and the temperature is reduced to about -5 degrees; prepare a high-concentration sodium nitrite solution, pre-cool to -5 degrees, and then slowly add drops to the previous In the solution. Do not add drops continuously. After dropping a little, use starch potassium iodide test paper to test the oxidation of the solution (in fact, to test the content of nitrous acid). If the test paper is purple-black and shows excessive nitrous acid, stop dropping. The drip can only be continued until the test paper is light blue-gray (indicating that nitrous acid is almost consumed). This cycle repeats, you should be patient and not rush. The whole reaction process should be protected from light to prevent the decomposition of diazonium salts. So until all sodium nitrite drops are finished, the solution should be clear and transparent. After the reaction is completed, an alkali solution such as sodium hydroxide is added, and then the temperature is slowly increased (to prevent the reaction from being violent), the diazonium salt decomposes to release nitrogen, and then combines with hydroxide ions to produce 5-chloro-2-hydroxy-3-Nitropyridine.

Last Update：2024-04-09 19:05:04