5-CHLORO-8-HYDROXYQUINOLINE

Name	5-Chloro-8-hydroxyquinoline
Synonyms	cloxiquine 5-CHLOROOXINE 5-CHLOROQUINOPHENOL 5-chloro-8-quinolino 5-Chloro-8-quinolinol 5-CHLORO-8-QUINOLINOL 5-chloroquinolin-8-ol 5-Chloro-8-oxyquinoline Clioquinol EP Impurity A 5-CHLORO-8-HYDROXYQUINOLINE 5-Chloro-8-hydroxyquinoline
CAS	130-16-5
EINECS	204-978-1
InChI	InChI=1/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
InChIKey	RWPWQYXFGFYJBA-UHFFFAOYSA-N

Molecular Formula	C9H6ClNO
Molar Mass	179.6
Density	1.2364 (rough estimate)
Melting Point	122-124°C(lit.)
Boling Point	348.7±22.0 °C(Predicted)
Flash Point	164.7°C
Solubility	0.019g/l (experimental)
Vapor Presure	0.003Pa at 25℃
Appearance	Bright green to gray powder
Color	Light green to gray
Merck	14,2422
BRN	5289
pKa	3.77±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Sensitive	Light Sensitive
Refractive Index	1.5330 (estimate)
MDL	MFCD00006788
Physical and Chemical Properties	Melting Point 121-126°C
Use	For Organic synthesis
In vitro study	Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis . Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner. Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells. Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.
In vivo study	Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model. Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	VC4590000
TSCA	Yes
HS Code	29334990

Raw Materials

NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
biological activity	Cloxiquine (5-Chloro-8-quinolinol, Dermofungin) is an anti-bacterial, anti-fungal, anti-aging and anti-tuberculosis drug.
Use	Used in organic synthesis Pesticide intermediates

Last Update：2024-04-09 02:00:06