5-Chloro-2(1H)-pyridinethione
5-Chloropyridine-2-thiol
CAS: 40771-41-3
Molecular Formula: C5H4ClNS
5-Chloro-2(1H)-pyridinethione - Names and Identifiers
| Name | 5-Chloropyridine-2-thiol |
| Synonyms | oro-2-pyridinethioL 5-Chloropyridine-2-thiol 5-Chloro-2-mercaptopyridine 3-Chloro-6-mercaptopyridine 5-Chloropyridine-2(1H)-thione 5-Chloro-2(1H)-pyridinethione 2(1H)-Pyridinethione, 5-chloro- |
| CAS | 40771-41-3 |
| InChI | InChI=1/C5H4ClNS/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8) |
5-Chloro-2(1H)-pyridinethione - Physico-chemical Properties
| Molecular Formula | C5H4ClNS |
| Molar Mass | 145.61 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | 195-198 |
| Boling Point | 183.5±50.0 °C(Predicted) |
| Flash Point | 89.173°C |
| Vapor Presure | 0.141mmHg at 25°C |
| pKa | 8.09±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.615 |
5-Chloro-2(1H)-pyridinethione - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
5-Chloro-2(1H)-pyridinethione - Introduction
5-Chloropyridine-2-thiol is an organic compound with the chemical formula C5H4ClNS.
Nature:
5-Chloropyridine-2-thiol is a colorless solid with a strong pungent odor. It has a melting point of 34-36°C and a boiling point of 215°C. The compound has good solubility in most organic solvents.
Use:
5-Chloropyridine-2-thiol is commonly used as an intermediate and reagent in organic synthesis. It can be used to synthesize other organic compounds, such as drugs, dyes and pesticides. In addition, it can also be used as a precursor for metal ligands and catalysts.
Preparation Method:
A common preparation method is to obtain 5-Chloropyridine-2-thiol by sulfurization of 5-chloro-2-bromopyridine. Specific steps are as follows:
1. Mix 5-chloro-2-bromopyridine with sodium sulfate, and add an appropriate amount of sodium carbonate.
2. Reaction at room temperature for a period of time, the reaction mixture will turn yellow.
3. The pH of the reaction mixture was adjusted with aqueous ammonia to produce 5-Chloropyridine-2-thiol.
4. Stirring and filtration were continued to give the pure product.
Safety Information:
5-Chloropyridine-2-thiol is an irritating chemical and direct contact with skin, eyes and mucous membranes should be avoided. Wear appropriate personal protective equipment such as gloves, glasses and protective clothing when using. At the same time, it should be operated in a well-ventilated place to avoid inhaling the vapor of chemical substances. If exposed or inhaled, rinse immediately with plenty of water and seek medical help.
Nature:
5-Chloropyridine-2-thiol is a colorless solid with a strong pungent odor. It has a melting point of 34-36°C and a boiling point of 215°C. The compound has good solubility in most organic solvents.
Use:
5-Chloropyridine-2-thiol is commonly used as an intermediate and reagent in organic synthesis. It can be used to synthesize other organic compounds, such as drugs, dyes and pesticides. In addition, it can also be used as a precursor for metal ligands and catalysts.
Preparation Method:
A common preparation method is to obtain 5-Chloropyridine-2-thiol by sulfurization of 5-chloro-2-bromopyridine. Specific steps are as follows:
1. Mix 5-chloro-2-bromopyridine with sodium sulfate, and add an appropriate amount of sodium carbonate.
2. Reaction at room temperature for a period of time, the reaction mixture will turn yellow.
3. The pH of the reaction mixture was adjusted with aqueous ammonia to produce 5-Chloropyridine-2-thiol.
4. Stirring and filtration were continued to give the pure product.
Safety Information:
5-Chloropyridine-2-thiol is an irritating chemical and direct contact with skin, eyes and mucous membranes should be avoided. Wear appropriate personal protective equipment such as gloves, glasses and protective clothing when using. At the same time, it should be operated in a well-ventilated place to avoid inhaling the vapor of chemical substances. If exposed or inhaled, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 21:11:58
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